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  • Smart, Sophie E.MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-189357
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189357URI
  • https://doi.org/10.1016/j.schres.2022.09.009DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding: Medical Research Council [MR/L011794/1]; National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service Foundation Trust; Kings College London; Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South London at Kings College Hospital National Health Service Foundation Trust; UK Medical Research Council [G0500817]; Research and Development Office of Northern Ireland; European Communitys Seventh Framework Program [HEALTH-F2-2010-241909]; UK National Institute of Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health, South London and Maudsley NHS Mental Health Foundation Trust (SLaM); Institute of Psychiatry, Psychology, and Neuroscience at Kings College London; Psychiatry Research Trust; Maudsley Charity Research Fund; European Community [HEALTH-F2-2010-241909, HEALTH-F2-2009-241909]; Swiss National Science Foundation [320030_135736/1, 320030120686, 324730-144064, 320030-173211, 171804]; National Center of Competence in Research (NCCR) "SYNAPSY - The Synaptic Bases of Mental Diseases" from the Swiss National Science Foundation [51AU40_125759]; Fondation Alamaya; Research Council of Norway [223273/F50, 300309, 283798]; South-Eastern Norway Regional Health Authority [2006233, 2006258, 2011085, 2014102, 2015088, 2017-112]; Ministry of Health of the Czech Republic [NU20-04-00393]; Instituto de Salud Carlos III [FIS 00/3095, PI020499, PI050427, PI060507]; Plan Nacional de Drogas Research Grant [2005-Orden sco/3246/2004]; SENY Fundatio Research Grant [CI 2005-0308007]; Fundacion Marques de Valdecilla [A/02/07, API07/011]; MINECO [SAF2016-76046-R, SAF2013-46292-R]; FEDER [SAF2016-76046-R, SAF2013-46292-R]; Wellcome Trust [042025, 052247, 064607]
  • IntroductionOur aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR.MethodsWe combined data from ten prospective, first-episode psychosis cohorts from across Europe and categorised patients as TR or non-treatment resistant (NTR) after a mean follow up of 4.18 years (s.d. = 3.20) for secondary data analysis. We identified a list of potential predictors from clinical and demographic data recorded at first-episode. These potential predictors were entered in two models: a multivariable logistic regression to identify which were independently associated with TR and a penalised logistic regression, which performed variable selection, to produce a parsimonious prediction model. This model was internally validated using a 5-fold, 50-repeat cross-validation optimism-correction.ResultsOur sample consisted of N = 2216 participants of which 385 (17 %) developed TR. Younger age of psychosis onset and fewer years in education were independently associated with increased odds of developing TR. The prediction model selected 7 out of 17 variables that, when combined, could quantify the risk of being TR better than chance. These included age of onset, years in education, gender, BMI, relationship status, alcohol use, and positive symptoms. The optimism-corrected area under the curve was 0.59 (accuracy = 64 %, sensitivity = 48 %, and specificity = 76 %).ImplicationsOur findings show that treatment resistance can be predicted, at first-episode of psychosis. Pending a model update and external validation, we demonstrate the potential value of prediction models for TR.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Agbedjro, DeborahDepartment of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)
  • Pardiñas, Antonio F.MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK (författare)
  • Ajnakina, OlesyaDepartment of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK (författare)
  • Alameda, LuisDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Centro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, Hospital Universitario Virgen del Rocio, IBiS, Universidad de Sevilla, Spain; TIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Andreassen, Ole A.Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (författare)
  • Barnes, Thomas R.E.Division of Psychiatry, Imperial College London, UK (författare)
  • Berardi, DomenicoDepartment of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy (författare)
  • Camporesi, SaraTIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Cleusix, MartineUnit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Conus, PhilippeTIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Crespo-Facorro, BenedictoCentro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, Hospital Universitario Virgen del Rocio, IBiS, Universidad de Sevilla, Spain (författare)
  • D'Andrea, GiuseppeDepartment of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy (författare)
  • Demjaha, ArsimeDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)
  • Di Forti, MartaSocial Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience; , King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK (författare)
  • Do, KimUnit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Doody, GillianDepartment of Medical Education, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK (författare)
  • Eap, Chin B.Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; Center for Research and Innovation in Clinical Pharmaceutical Sciences, University of Lausanne, Switzerland; Institute of Pharmaceutical Sciences of Western, Switzerland, University of Geneva, University of Lausanne (författare)
  • Ferchiou, AzizUniv Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France (författare)
  • Guidi, LorenzoDepartment of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum – University of Bologna, Bologna, Italy (författare)
  • Homman, LinaLinköpings universitet,Avdelningen för funktionsnedsättning och samhälle,Filosofiska fakulteten(Swepub:liu)homli50 (författare)
  • Jenni, RaoulUnit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Joyce, EileenDepartment of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK (författare)
  • Kassoumeri, LauraDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)
  • Lastrina, OrnellaDepartment of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum – University of Bologna, Bologna, Italy (författare)
  • Melle, IngridNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (författare)
  • Morgan, CraigHealth Service and Population Research, King's College London, London, UK; Centre for Society and Mental Health, King's College London, London, UK (författare)
  • O'Neill, Francis A.Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast, Belfast, UK (författare)
  • Pignon, BaptisteUniv Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France (författare)
  • Restellini, RomeoTIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland (författare)
  • Richard, Jean-RomainUniv Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France (författare)
  • Simonsen, CarmenNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Early Intervention in Psychosis Advisory Unit for South East Norway (TIPS Sør-Øst), Division of Mental Health and Addiction, Oslo University Hospital, Norway (författare)
  • Španiel, FilipDepartment of Applied Neuroscience and Neuroimaging, National Institute of Mental Health, Klecany, Czechia; Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czechia (författare)
  • Szöke, AndreiUniv Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France (författare)
  • Tarricone, IlariaHealth Service and Population Research, King's College London, London, UK (författare)
  • Tortelli, AndreaUniv Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; Groupe Hospitalier Universitaire Psychiatrie Neurosciences Paris, Pôle Psychiatrie Précarité, Paris, France (författare)
  • Üçok, AlpIstanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey (författare)
  • Vázquez-Bourgon, JavierCentro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, University Hospital Marques de Valdecilla - Instituto de Investigación Marques de Valdecilla (IDIVAL), Santander, Spain; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain (författare)
  • Murray, Robin M.Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)
  • Walters, James T.R.MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK (författare)
  • Stahl, DanielDepartment of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (författare)
  • MacCabe, James H.Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK (författare)
  • MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKDepartment of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Schizophrenia Research: Elsevier2500920-99641573-2509

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