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Evolution of human ...
Evolution of human endogenous retroviral sequences : a conceptual account
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- Blikstad, Vidar (författare)
- Uppsala universitet,Klinisk virologi,blomberg
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- Benachenhou, Farid (författare)
- Uppsala universitet,Klinisk virologi,blomberg
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- Sperber, Göran O. (författare)
- Uppsala universitet,Fysiologi,Sperber
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- Blomberg, Jonas (författare)
- Uppsala universitet,Klinisk virologi,blomberg
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(creator_code:org_t)
- 2008-09-27
- 2008
- Engelska.
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 65:21, s. 3348-3365
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endogenous retroviruses (ERVs) most likely are remnants of ancient retroviral infections. ERVs preserve functions of exogenous retroviruses to a varying extent, and can be parasites, symbionts or more or less neutral genetic 'junk'.Their evolution has two facets, pre- and post-endogenization. Although the two are not clearly separated, the first pertains to retroviral evolution in general and the second to the fate of repetitive DNA and the evolution of the host organism and its genome. The study of ERVs provides much material for the understanding of retroviral evolution. This sequence archive reflects the history of successes and shortcomings of antiviral resistance, but also of strategic evolutionary decisions regarding genome organization and new gene acquisition. This review discusses retroviral evolution illustrated through HERVs, bioinformatic prerequisites for ERV studies, the endogenization process and HERV evolution post-endogenization, including relation to disease. (Part of a multi-author review).
Nyckelord
- Bioinformatics
- Endogenous retrovirus
- Evolution
- Lateral transfer
- Sequence recognition
- Vertebrate genome
- Virulence
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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