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αII-spectrin breakd...
αII-spectrin breakdown products (SBDPs) : diagnosis and outcome in severe traumatic brain injury patients
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- Mondello, Stefania (författare)
- Department of Clinical Programs and Center of Innovative Research, and Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
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- Robicsek, Steven A. (författare)
- Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
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- Gabrielli, Andrea (författare)
- Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
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- Brophy, Gretchen M. (författare)
- Department of Pharmacy and Neurosurgery, Virginia Commonwealth Universitya, Richmond, Virginia, United States
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- Papa, Linda (författare)
- Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, United States
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- Tepas, Joseph (författare)
- Department of Surgery and Pediatrics, University of Florida, Jacksonville, Florida, United States
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- Robertson, Claudia (författare)
- Department of Critical Care, Baylor College of Medicine, Houston, Texas, United States
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, University of Pécs, Pécs, Hungary
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- Scharf, Dancia (författare)
- Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
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- Jixiang, Mo (författare)
- Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
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- Akinyi, Linnet (författare)
- Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
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- Muller, Uwe (författare)
- Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
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- Wang, Kevin K.W. (författare)
- Center of Innovative Research, Banyan Biomarkers Inc., and University of Florida, Department of Psychiatry, Gainesville, Florida, United States
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- Hayes, Ronald L. (författare)
- Department of Clinical Programs, Banyan Biomarkers Inc., and University of Florida, Department of Anesthesiology, Gainesville, Florida, United States
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(creator_code:org_t)
- Mary Ann Liebert, 2010
- 2010
- Engelska.
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Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 27:7, s. 1203-1213
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyzed 40 adult patients with severe TBI (Glasgow Coma Scale [GCS] score 6 ng/mL) and SBDP120 levels (>17.55 ng/mL) strongly predicted death (odds ratio 5.9 for SBDP145, and 18.34 for SBDP120). The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Mondello, Stefan ...
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Robicsek, Steven ...
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Gabrielli, Andre ...
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Brophy, Gretchen ...
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Papa, Linda
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Tepas, Joseph
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visa fler...
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Robertson, Claud ...
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Büki, Andras, 19 ...
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Scharf, Dancia
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Jixiang, Mo
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Akinyi, Linnet
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Muller, Uwe
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Wang, Kevin K.W.
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Hayes, Ronald L.
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