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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010303naa a2200733 4500
001oai:DiVA.org:umu-215705
003SwePub
008231113s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153935457
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2157052 URI
0247 a https://doi.org/10.1183/23120541.00269-20232 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1539354572 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Yasinska, Valentynau Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden4 aut
2451 0a Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
264 1b European Respiratory Society,c 2023
338 a electronic2 rdacarrier
520 a Rationale: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure.Methods: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study.Measurements and main results: The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months.Conclusion: The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
7001 a Gómez, Cristinau Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Kolmert, Johanu Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Ericsson, Magnusu Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden; Laboratoire AntiDopage Français, Université Paris-Saclay, Châtenay-Malabry, France4 aut
7001 a Pohanka, Antonu Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a James, Annau Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Andersson, Lars I.u Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Sparreman-Mikus, Mariau Karolinska Institutet4 aut
7001 a Sousa, Ana R.u Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom4 aut
7001 a Riley, John H.u Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom4 aut
7001 a Bates, Stewartu Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom4 aut
7001 a Bakke, Per S.u Institute of Clinical Science, University of Bergen, Bergen, Norway4 aut
7001 a Kermani, Nazanin Zounematu National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Caruso, Massimou Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy4 aut
7001 a Chanez, Pascalu Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France4 aut
7001 a Fowler, Stephen J.u Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom4 aut
7001 a Geiser, Thomasu Department of Pulmonary Medicine, University Hospital, University of Bern, Bern, Switzerland4 aut
7001 a Howarth, Peter H.u Faculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom4 aut
7001 a Horváth, Ildikóu Department of Public Health, Semmelweis University, Budapest, Hungary; National Koranyi Institute for Pulmonology, Budapest, Hungary4 aut
7001 a Krug, Norbertu Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany4 aut
7001 a Montuschi, Paolou National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom; Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy4 aut
7001 a Sanak, Mareku Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland4 aut
7001 a Behndig, Annelie F.,d 1963-u Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)anbe0145
7001 a Shaw, Dominick E.u Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom4 aut
7001 a Knowles, Richard G.u Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom4 aut
7001 a Dahlén, Barbrou Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a van der Zee, Anke-Hilse Maitlandu Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands4 aut
7001 a Sterk, Peter J.u Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands4 aut
7001 a Djukanovic, Ratkou Faculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom4 aut
7001 a Adcock, Ian M.u National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Chung, Kian Fanu National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Wheelock, Craig E.u Karolinska Institutet4 aut
7001 a Dahlén, Sven-Eriku Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Jonsson, Eva Wikströmu Karolinska Institutet4 aut
7102 a Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Swedenb Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 org
7730 t ERJ Open Researchd : European Respiratory Societyg 9:5q 9:5x 2312-0541
8564 u https://doi.org/10.1183/23120541.00269-2023y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1811585/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215705
8564 8u https://doi.org/10.1183/23120541.00269-2023
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153935457

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