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WFRF:(Andersson Marie A.)
 

Sökning: WFRF:(Andersson Marie A.) > Estrogen receptor-b...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005841naa a2200925 4500
001oai:gup.ub.gu.se/75316
003SwePub
008240528s2004 | |||||||||||000 ||eng|
009oai:research.chalmers.se:03f7dd9a-46ff-4693-9de4-dc956442c033
009oai:prod.swepub.kib.ki.se:19813678
0247 a https://gup.ub.gu.se/publication/753162 URI
0247 a https://research.chalmers.se/publication/753162 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:198136782 URI
0247 a https://doi.org/10.1359/JBMR.03012032 DOI
040 a (SwePub)gud (SwePub)cthd (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chagin, A Su Karolinska Institutet4 aut
2451 0a Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice.
264 1c 2004
520 a To determine the long-term role of ER beta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ER beta-/-, ER alpha-/-, and ER alpha-/- beta-/- mice. Our results show that ER beta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates. INTRODUCTION: Estrogen affects skeletal growth and promotes growth plate fusion in humans. In rodents, the growth plates do not fuse after sexual maturation, but prolonged treatment with supraphysiological levels of estradiol has the capacity to fuse the growth plates. It should be emphasized that the estrogen receptor (ER) alpha-/- and the ER alpha-/- beta-/-, but not the ER beta-/-, mouse models have clearly increased serum levels of estradiol. MATERIALS AND METHODS: The skeletal growth was monitored by X-ray and dynamic histomorphometry, and the growth plates were analyzed by quantitative histology, calcein double labeling, bromodeoxyuridine (BrdU) incorporation, and TUNEL assay in 4- and 18-month-old female ER beta-/-, ER alpha-/-, and ER alpha-/- beta-/- mice. RESULTS: Young adult (4-month-old) ER beta-/- mice demonstrated an increased axial- and appendicular-skeletal growth, supporting the notion that ER beta inhibits skeletal growth in young adult female mice. Interestingly, the growth plates were consistently fused in the appendicular skeleton of 18-month-old female ER alpha-/- mice. This fusion of growth plates, caused by a prolonged exposure to supraphysiological levels of estradiol in female ER alpha-/- mice, must be mediated through ER beta because old ER alpah-/- beta-/- mice displayed unchanged, unfused growth plates. CONCLUSIONS: Our results confirm that ER beta is a physiological inhibitor of appendicular- and axial-skeletal growth in young adult female mice. Furthermore, we made the novel observation that ER beta, after prolonged supraphysiological estradiol exposure, has the capacity to mediate growth plate fusion in old female mice.
653 a Absorptiometry
653 a Photon
653 a Age Factors
653 a Animals
653 a Apoptosis
653 a physiology
653 a Body Weights and Measures
653 a Bone Development
653 a physiology
653 a Cell Count
653 a Cell Division
653 a physiology
653 a Cell Size
653 a physiology
653 a Chondrocytes
653 a cytology
653 a metabolism
653 a Estrogen Receptor alpha
653 a Estrogen Receptor beta
653 a Female
653 a Femur
653 a anatomy & histology
653 a cytology
653 a growth & development
653 a Growth Plate
653 a anatomy & histology
653 a cytology
653 a growth & development
653 a Intervertebral Disk
653 a anatomy & histology
653 a Mice
653 a Mice
653 a Knockout
653 a Receptors
653 a Estrogen
653 a genetics
653 a physiology
653 a Spine
653 a anatomy & histology
653 a cytology
653 a growth & development
653 a Tibia
653 a cytology
653 a growth & development
653 a growth & development
7001 a Lindberg, Marie K,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine,University of Gothenburg4 aut
7001 a Andersson, Niklas,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg4 aut0 (Swepub:cth)nikander
7001 a Movérare-Skrtic, Sofiau Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg4 aut0 (Swepub:gu)xmovso
7001 a Gustafsson, J Au Karolinska Institutet4 aut
7001 a Sävendahl, Larsu Karolinska Institutet4 aut
7001 a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg4 aut0 (Swepub:gu)xohlcl
7102 a Karolinska Institutetb Institutionen för invärtesmedicin4 org
7730 t Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Researchg 19:1, s. 72-7q 19:1<72-7x 0884-0431
8564 8u https://gup.ub.gu.se/publication/75316
8564 8u https://research.chalmers.se/publication/75316
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:19813678
8564 8u https://doi.org/10.1359/JBMR.0301203

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