Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

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Fältnamn	Indikatorer	Metadata
000		09916naa a2202317 4500
001		oai:lup.lub.lu.se:19739b80-cdd4-4db7-b175-028cfda89d8f
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/32440002 URI
024	7	a https://doi.org/10.1016/j.ajhg.2012.08.0322 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Asselbergs, Folkert W.4 aut
245	1 0	a Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
264	1	b Elsevier BV,c 2012
520		a Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Guo, Yiran4 aut
700	1	a van Iperen, Erik P. A.4 aut
700	1	a Sivapalaratnam, Suthesh4 aut
700	1	a Tragante, Vinicius4 aut
700	1	a Lanktree, Matthew B.4 aut
700	1	a Lange, Leslie A.4 aut
700	1	a Almoguera, Berta4 aut
700	1	a Appelman, Yolande E.4 aut
700	1	a Barnard, John4 aut
700	1	a Baumert, Jens4 aut
700	1	a Beitelshees, Amber L.4 aut
700	1	a Bhangale, Tushar R.4 aut
700	1	a Chen, Yii-Der Ida4 aut
700	1	a Gaunt, Tom R.4 aut
700	1	a Gong, Yan4 aut
700	1	a Hopewell, Jemma C.4 aut
700	1	a Johnson, Toby4 aut
700	1	a Kleber, Marcus E.4 aut
700	1	a Langaee, Taimour Y.4 aut
700	1	a Li, Mingyao4 aut
700	1	a Li, Yun R.4 aut
700	1	a Liu, Kiang4 aut
700	1	a McDonough, Caitrin W.4 aut
700	1	a Meijs, Matthijs El.4 aut
700	1	a Middelberg, Rita P. S.4 aut
700	1	a Musunuru, Kiran4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a O'Connell, Jeffery R.4 aut
700	1	a Padmanabhan, Sandosh4 aut
700	1	a Pankow, James S.4 aut
700	1	a Pankratz, Nathan4 aut
700	1	a Rafelt, Suzanne4 aut
700	1	a Rajagopalan, Ramakrishnan4 aut
700	1	a Romaine, Simon P. R.4 aut
700	1	a Schork, Nicholas J.4 aut
700	1	a Shaffer, Jonathan4 aut
700	1	a Shen, Haiqing4 aut
700	1	a Smith, Erin N.4 aut
700	1	a Tischfield, Sam E.4 aut
700	1	a van der Most, Peter J.4 aut
700	1	a van Vliet-Ostaptchouk, Jana V.4 aut
700	1	a Verweij, Niek4 aut
700	1	a Volcik, Kelly A.4 aut
700	1	a Zhang, Li4 aut
700	1	a Bailey, Kent R.4 aut
700	1	a Bailey, Kristian M.4 aut
700	1	a Bauer, Florianne4 aut
700	1	a Boer, Jolanda M. A.4 aut
700	1	a Braund, Peter S.4 aut
700	1	a Burt, Amber4 aut
700	1	a Burton, Paul R.4 aut
700	1	a Buxbaum, Sarah G.4 aut
700	1	a Chen, Wei4 aut
700	1	a Cooper-DeHoff, Rhonda M.4 aut
700	1	a Cupples, L. Adrienne4 aut
700	1	a deJong, Jonas S.4 aut
700	1	a Delles, Christian4 aut
700	1	a Duggan, David4 aut
700	1	a Fornage, Myriam4 aut
700	1	a Furlong, Clement E.4 aut
700	1	a Glazer, Nicole4 aut
700	1	a Gums, John G.4 aut
700	1	a Hastie, Claire4 aut
700	1	a Holmes, Michael V.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Kirkland, Susan A.4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Klein, Ronald4 aut
700	1	a Klein, Barbara E.4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Kottke-Marchant, Kandice4 aut
700	1	a Kumari, Meena4 aut
700	1	a LaCroix, Andrea Z.4 aut
700	1	a Mallela, Laya4 aut
700	1	a Murugesan, Gurunathan4 aut
700	1	a Ordovas, Jose4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Post, Wendy S.4 aut
700	1	a Saxena, Richa4 aut
700	1	a Scharnagl, Hubert4 aut
700	1	a Schreiner, Pamela J.4 aut
700	1	a Shah, Tina4 aut
700	1	a Shields, Denis C.4 aut
700	1	a Shimbo, Daichi4 aut
700	1	a Srinivasan, Sathanur R.4 aut
700	1	a Stolk, Ronald P.4 aut
700	1	a Swerdlow, Daniel I.4 aut
700	1	a Taylor Jr, Herman A.4 aut
700	1	a Topo, Eric J.4 aut
700	1	a Toskala, Elina4 aut
700	1	a van Pelt, Joost L.4 aut
700	1	a van Setten, Jessica4 aut
700	1	a Yusuf, Salim4 aut
700	1	a Whittaker, John C.4 aut
700	1	a Zwinderman, A. H.4 aut
700	1	a Anand, Sonia S.4 aut
700	1	a Balmforth, Anthony J.4 aut
700	1	a Berenson, Gerald S.4 aut
700	1	a Bezzina, Connie R.4 aut
700	1	a Boehm, Bernhard O.4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Casas, Juan P.4 aut
700	1	a Caulfield, Mark J.4 aut
700	1	a Clarke, Robert4 aut
700	1	a Connell, John M.4 aut
700	1	a Cruickshanks, Karen J.4 aut
700	1	a Davidson, Karina W.4 aut
700	1	a Day, Ian N. M.4 aut
700	1	a de Bakker, Paul I. W.4 aut
700	1	a Doevendans, Pieter A.4 aut
700	1	a Dominiczak, Anna E.4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Hartman, Catharina A.4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Hillege, Hans L.4 aut
700	1	a Hofker, Marten H.4 aut
700	1	a Humphries, Steve E.4 aut
700	1	a Jarvik, Gail P.4 aut
700	1	a Johnson, Julie A.4 aut
700	1	a Kaess, Bernhard M.4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Lawlor, Debbie A.4 aut
700	1	a Maerz, Winfried4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Mitchell, Braxton D.4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a Munroe, Patricia B.4 aut
700	1	a Murray, Sarah S.4 aut
700	1	a Newhouse, Stephen J.4 aut
700	1	a Onland-Moret, N. Charlotte4 aut
700	1	a Poulter, Neil4 aut
700	1	a Psaty, Bruce4 aut
700	1	a Redline, Susan4 aut
700	1	a Rich, Stephen S.4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Schunkert, Heribert4 aut
700	1	a Sever, Peter4 aut
700	1	a Shuldiner, Alan R.4 aut
700	1	a Silverstein, Roy L.4 aut
700	1	a Stanton, Alice4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Trip, Mieke D.4 aut
700	1	a Tsai, Michael Y.4 aut
700	1	a van der Harst, Pim4 aut
700	1	a van der Schoot, Ellen4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Verschuren, W. M. Monique4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Wilde, Arthur A. M.4 aut
700	1	a Wolffenbuttel, Bruce H. R.4 aut
700	1	a Whitfield, John B.4 aut
700	1	a Hovingh, G. Kees4 aut
700	1	a Ballantyne, Christie M.4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Wilson, James G.4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Reiner, Alex P.4 aut
700	1	a Hegele, Robert A.4 aut
700	1	a Kastelein, John J. P.4 aut
700	1	a Hingorani, Aroon D.4 aut
700	1	a Talmud, Philippa J.4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Elbers, Clara C.4 aut
700	1	a Keating, Brendan J.4 aut
700	1	a Drenos, Fotios4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t American Journal of Human Geneticsd : Elsevier BVg 91:5, s. 823-838q 91:5<823-838x 0002-9297
856	4	u http://dx.doi.org/10.1016/j.ajhg.2012.08.032y FULLTEXT
856	4	u https://doi.org/10.1016/j.ajhg.2012.08.032
856	4 8	u https://lup.lub.lu.se/record/3244000
856	4 8	u https://doi.org/10.1016/j.ajhg.2012.08.032

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Av författaren/redakt...: Asselbergs, Folk ...; Guo, Yiran; van Iperen, Erik ...; Sivapalaratnam, ...; Tragante, Vinici ...; Lanktree, Matthe ...; visa fler...; Lange, Leslie A.; Almoguera, Berta; Appelman, Yoland ...; Barnard, John; Baumert, Jens; Beitelshees, Amb ...; Bhangale, Tushar ...; Chen, Yii-Der Id ...; Gaunt, Tom R.; Gong, Yan; Hopewell, Jemma ...; Johnson, Toby; Kleber, Marcus E ...; Langaee, Taimour ...; Li, Mingyao; Li, Yun R.; Liu, Kiang; McDonough, Caitr ...; Meijs, Matthijs ...; Middelberg, Rita ...; Musunuru, Kiran; Nelson, Christop ...; O'Connell, Jeffe ...; Padmanabhan, San ...; Pankow, James S.; Pankratz, Nathan; Rafelt, Suzanne; Rajagopalan, Ram ...; Romaine, Simon P ...; Schork, Nicholas ...; Shaffer, Jonatha ...; Shen, Haiqing; Smith, Erin N.; Tischfield, Sam ...; van der Most, Pe ...; van Vliet-Ostapt ...; Verweij, Niek; Volcik, Kelly A.; Zhang, Li; Bailey, Kent R.; Bailey, Kristian ...; Bauer, Florianne; Boer, Jolanda M. ...; Braund, Peter S.; Burt, Amber; Burton, Paul R.; Buxbaum, Sarah G ...; Chen, Wei; Cooper-DeHoff, R ...; Cupples, L. Adri ...; deJong, Jonas S.; Delles, Christia ...; Duggan, David; Fornage, Myriam; Furlong, Clement ...; Glazer, Nicole; Gums, John G.; Hastie, Claire; Holmes, Michael ...; Illig, Thomas; Kirkland, Susan ...; Kivimaki, Mika; Klein, Ronald; Klein, Barbara E ...; Kooperberg, Char ...; Kottke-Marchant, ...; Kumari, Meena; LaCroix, Andrea ...; Mallela, Laya; Murugesan, Gurun ...; Ordovas, Jose; Ouwehand, Willem ...; Post, Wendy S.; Saxena, Richa; Scharnagl, Huber ...; Schreiner, Pamel ...; Shah, Tina; Shields, Denis C ...; Shimbo, Daichi; Srinivasan, Sath ...; Stolk, Ronald P.; Swerdlow, Daniel ...; Taylor Jr, Herma ...; Topo, Eric J.; Toskala, Elina; van Pelt, Joost ...; van Setten, Jess ...; Yusuf, Salim; Whittaker, John ...; Zwinderman, A. H ...; Anand, Sonia S.; Balmforth, Antho ...; Berenson, Gerald ...; Bezzina, Connie ...; Boehm, Bernhard ...; Boerwinkle, Eric; Casas, Juan P.; Caulfield, Mark ...; Clarke, Robert; Connell, John M.; Cruickshanks, Ka ...; Davidson, Karina ...; Day, Ian N. M.; de Bakker, Paul ...; Doevendans, Piet ...; Dominiczak, Anna ...; Hall, Alistair S ...; Hartman, Cathari ...; Hengstenberg, Ch ...; Hillege, Hans L.; Hofker, Marten H ...; Humphries, Steve ...; Jarvik, Gail P.; Johnson, Julie A ...; Kaess, Bernhard ...; Kathiresan, Seka ...; Koenig, Wolfgang; Lawlor, Debbie A ...; Maerz, Winfried; Melander, Olle; Mitchell, Braxto ...; Montgomery, Gran ...; Munroe, Patricia ...; Murray, Sarah S.; Newhouse, Stephe ...; Onland-Moret, N. ...; Poulter, Neil; Psaty, Bruce; Redline, Susan; Rich, Stephen S.; Rotter, Jerome I ...; Schunkert, Herib ...; Sever, Peter; Shuldiner, Alan ...; Silverstein, Roy ...; Stanton, Alice; Thorand, Barbara; Trip, Mieke D.; Tsai, Michael Y.; van der Harst, P ...; van der Schoot, ...; van der Schouw, ...; Verschuren, W. M ...; Watkins, Hugh; Wilde, Arthur A. ...; Wolffenbuttel, B ...; Whitfield, John ...; Hovingh, G. Kees; Ballantyne, Chri ...; Wijmenga, Cisca; Reilly, Muredach ...; Martin, Nicholas ...; Wilson, James G.; Rader, Daniel J.; Samani, Nilesh J ...; Reiner, Alex P.; Hegele, Robert A ...; Kastelein, John ...; Hingorani, Aroon ...; Talmud, Philippa ...; Hakonarson, Hako ...; Elbers, Clara C.; Keating, Brendan ...; Drenos, Fotios; visa färre...

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