WFRF:(Carreira C.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06124naa a2201393 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141150866 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1411508662 URI |
| 024 | 7 | a https://doi.org/10.1136/annrheumdis-2018-2141272 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Acosta-Herrera, M4 aut |
| 245 | 1 0 | a Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases |
| 264 | c 2018-12-20 | |
| 264 | 1 | b BMJ,c 2019 |
| 520 | a Immune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions with overlapping clinical symptoms and elevated familial aggregation, which suggests the existence of a shared genetic component. In order to identify this genetic background in a systematic fashion, we performed the first cross-disease genome-wide meta-analysis in systemic seropositive rheumatic diseases, namely, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and idiopathic inflammatory myopathies.MethodsWe meta-analysed ~6.5 million single nucleotide polymorphisms in 11 678 cases and 19 704 non-affected controls of European descent populations. The functional roles of the associated variants were interrogated using publicly available databases.ResultsOur analysis revealed five shared genome-wide significant independent loci that had not been previously associated with these diseases: NAB1, KPNA4-ARL14, DGQK, LIMK1 and PRR12. All of these loci are related with immune processes such as interferon and epidermal growth factor signalling, response to methotrexate, cytoskeleton dynamics and coagulation cascade. Remarkably, several of the associated loci are known key players in autoimmunity, which supports the validity of our results. All the associated variants showed significant functional enrichment in DNase hypersensitivity sites, chromatin states and histone marks in relevant immune cells, including shared expression quantitative trait loci. Additionally, our results were significantly enriched in drugs that are being tested for the treatment of the diseases under study.ConclusionsWe have identified shared new risk loci with functional value across diseases and pinpoint new potential candidate loci that could be further investigated. Our results highlight the potential of drug repositioning among related systemic seropositive rheumatic IMIDs. | |
| 700 | 1 | a Kerick, M4 aut |
| 700 | 1 | a Gonzalez-Serna, D4 aut |
| 700 | 1 | a Wijmenga, C4 aut |
| 700 | 1 | a Franke, A4 aut |
| 700 | 1 | a Gregersen, PK4 aut |
| 700 | 1 | a Padyukov, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Worthington, J4 aut |
| 700 | 1 | a Vyse, TJ4 aut |
| 700 | 1 | a Alarcon-Riquelme, MEu Karolinska Institutet4 aut |
| 700 | 1 | a Mayes, MD4 aut |
| 700 | 1 | a Martin, J4 aut |
| 700 | 1 | a Miller, FW4 aut |
| 700 | 1 | a Chen, W4 aut |
| 700 | 1 | a O'Hanlon, TP4 aut |
| 700 | 1 | a Cooper, RG4 aut |
| 700 | 1 | a Vencovsky, J4 aut |
| 700 | 1 | a Rider, LG4 aut |
| 700 | 1 | a Danko, K4 aut |
| 700 | 1 | a Wedderburn, LR4 aut |
| 700 | 1 | a Lundberg, IEu Karolinska Institutet4 aut |
| 700 | 1 | a Pachman, LM4 aut |
| 700 | 1 | a Reed, AM4 aut |
| 700 | 1 | a Ytterberg, SR4 aut |
| 700 | 1 | a Selva-O'Callaghan, A4 aut |
| 700 | 1 | a Radstake, TR4 aut |
| 700 | 1 | a Isenberg, DA4 aut |
| 700 | 1 | a Chinoy, H4 aut |
| 700 | 1 | a Ollier, WER4 aut |
| 700 | 1 | a Scheet, P4 aut |
| 700 | 1 | a Peng, B4 aut |
| 700 | 1 | a Lee, A4 aut |
| 700 | 1 | a Lamb, JA4 aut |
| 700 | 1 | a Amos, CI4 aut |
| 700 | 1 | a Denton, C4 aut |
| 700 | 1 | a Hilton-Jones, D4 aut |
| 700 | 1 | a Plotz, PH4 aut |
| 700 | 1 | a Varsani, H4 aut |
| 700 | 1 | a Radstake, TRDJ4 aut |
| 700 | 1 | a Gorlova, O4 aut |
| 700 | 1 | a Rueda, B4 aut |
| 700 | 1 | a Martin, JE4 aut |
| 700 | 1 | a Alizadeh, BZ4 aut |
| 700 | 1 | a Palomino-Morales, R4 aut |
| 700 | 1 | a Coenen, MJ4 aut |
| 700 | 1 | a Vonk, MC4 aut |
| 700 | 1 | a Voskuyl, AE4 aut |
| 700 | 1 | a Scheurwegh, AJ4 aut |
| 700 | 1 | a Broen, JC4 aut |
| 700 | 1 | a van Riel, PLCM4 aut |
| 700 | 1 | a van 't Slot, R4 aut |
| 700 | 1 | a Italiaander, A4 aut |
| 700 | 1 | a Ophoff, RA4 aut |
| 700 | 1 | a Riemekasten, G4 aut |
| 700 | 1 | a Hunzelmann, N4 aut |
| 700 | 1 | a Simeon, CP4 aut |
| 700 | 1 | a Ortego-Centeno, N4 aut |
| 700 | 1 | a Gonzalez-Gay, MA4 aut |
| 700 | 1 | a Gonzalez-Escribano, MF4 aut |
| 700 | 1 | a Airo, P4 aut |
| 700 | 1 | a van Laar, J4 aut |
| 700 | 1 | a Herrick, A4 aut |
| 700 | 1 | a Hesselstrand, R4 aut |
| 700 | 1 | a Smith, V4 aut |
| 700 | 1 | a de Keyser, F4 aut |
| 700 | 1 | a Houssiau, F4 aut |
| 700 | 1 | a Chee, MM4 aut |
| 700 | 1 | a Madhok, R4 aut |
| 700 | 1 | a Shiels, P4 aut |
| 700 | 1 | a Westhovens, R4 aut |
| 700 | 1 | a Kreuter, A4 aut |
| 700 | 1 | a Kiener, H4 aut |
| 700 | 1 | a de Baere, E4 aut |
| 700 | 1 | a Witte, T4 aut |
| 700 | 1 | a Klareskog, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Beretta, L4 aut |
| 700 | 1 | a Scorza, R4 aut |
| 700 | 1 | a Lie, BA4 aut |
| 700 | 1 | a Hoffman-Vold, AM4 aut |
| 700 | 1 | a Carreira, P4 aut |
| 700 | 1 | a Varga, J4 aut |
| 700 | 1 | a Hinchcliff, M4 aut |
| 700 | 1 | a Lee, AT4 aut |
| 700 | 1 | a Ying, J4 aut |
| 700 | 1 | a Han, Y4 aut |
| 700 | 1 | a Weng, SF4 aut |
| 700 | 1 | a Wigley, FM4 aut |
| 700 | 1 | a Hummers, L4 aut |
| 700 | 1 | a Nelson, JL4 aut |
| 700 | 1 | a Agarwal, SK4 aut |
| 700 | 1 | a Assassi, S4 aut |
| 700 | 1 | a Gourh, P4 aut |
| 700 | 1 | a Tan, FK4 aut |
| 700 | 1 | a Koeleman, BPC4 aut |
| 700 | 1 | a Arnett, FC4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Annals of the rheumatic diseasesd : BMJg 78:3, s. 311-319q 78:3<311-319x 1468-2060x 0003-4967 |
| 856 | 4 | u https://europepmc.org/articles/pmc6800208?pdf=render |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141150866 |
| 856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2018-214127 |
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- Acosta-Herrera, ...
- Kerick, M
- Gonzalez-Serna, ...
- Wijmenga, C
- Franke, A
- Gregersen, PK
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- Padyukov, L
- Worthington, J
- Vyse, TJ
- Alarcon-Riquelme ...
- Mayes, MD
- Martin, J
- Miller, FW
- Chen, W
- O'Hanlon, TP
- Cooper, RG
- Vencovsky, J
- Rider, LG
- Danko, K
- Wedderburn, LR
- Lundberg, IE
- Pachman, LM
- Reed, AM
- Ytterberg, SR
- Selva-O'Callagha ...
- Radstake, TR
- Isenberg, DA
- Chinoy, H
- Ollier, WER
- Scheet, P
- Peng, B
- Lee, A
- Lamb, JA
- Amos, CI
- Denton, C
- Hilton-Jones, D
- Plotz, PH
- Varsani, H
- Radstake, TRDJ
- Gorlova, O
- Rueda, B
- Martin, JE
- Alizadeh, BZ
- Palomino-Morales ...
- Coenen, MJ
- Vonk, MC
- Voskuyl, AE
- Scheurwegh, AJ
- Broen, JC
- van Riel, PLCM
- van 't Slot, R
- Italiaander, A
- Ophoff, RA
- Riemekasten, G
- Hunzelmann, N
- Simeon, CP
- Ortego-Centeno, ...
- Gonzalez-Gay, MA
- Gonzalez-Escriba ...
- Airo, P
- van Laar, J
- Herrick, A
- Hesselstrand, R
- Smith, V
- de Keyser, F
- Houssiau, F
- Chee, MM
- Madhok, R
- Shiels, P
- Westhovens, R
- Kreuter, A
- Kiener, H
- de Baere, E
- Witte, T
- Klareskog, L
- Beretta, L
- Scorza, R
- Lie, BA
- Hoffman-Vold, AM
- Carreira, P
- Varga, J
- Hinchcliff, M
- Lee, AT
- Ying, J
- Han, Y
- Weng, SF
- Wigley, FM
- Hummers, L
- Nelson, JL
- Agarwal, SK
- Assassi, S
- Gourh, P
- Tan, FK
- Koeleman, BPC
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