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Sökning: WFRF:(Irwin David J) > (2015-2019) > Diffusion tensor MR...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005857naa a2200469 4500
001oai:lup.lub.lu.se:8922b8c5-3ca7-459b-b559-d5765325b777
003SwePub
008191216s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8922b8c5-3ca7-459b-b559-d5765325b7772 URI
0247 a https://doi.org/10.1148/radiol.20191904062 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Spotorno, Nicolau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of Pennsylvania4 aut0 (Swepub:lu)ni1407sp
2451 0a Diffusion tensor MRI to distinguish progressive supranuclear palsy from a-synucleinopathies
264 1b Radiological Society of North America (RSNA),c 2019
300 a 8 s.
520 a Background: The differential diagnosis of progressive supranuclear palsy (PSP) and Lewy body disorders, which include Parkinson disease and dementia with Lewy bodies, is often challenging due to the overlapping symptoms. Purpose: To develop a diagnostic tool based on diffusion tensor imaging (DTI) to distinguish between PSP and Lewy body disorders at the individual-subject level. Materials and Methods: In this retrospective study, skeletonized DTI metrics were extracted from two independent data sets: the discovery cohort from the Swedish BioFINDER study and the validation cohort from the Penn Frontotemporal Degeneration Center (data collected between 2010 and 2018). Based on previous neuroimaging studies and neuropathologic evidence, a combination of regions hypothesized to be sensitive to pathologic features of PSP were identified (ie, the superior cerebellar peduncle and frontal white matter) and fractional anisotropy (FA) was used to compute an FA score for each individual. Classification performances were assessed by using logistic regression and receiver operating characteristic analysis. Results: In the discovery cohort, 16 patients with PSP (mean age 6 standard deviation, 73 years 6 5; eight women, eight men), 34 patients with Lewy body disorders (mean age, 71 years 6 6; 14 women, 20 men), and 44 healthy control participants (mean age, 66 years 6 8; 26 women, 18 men) were evaluated. The FA score distinguished between clinical PSP and Lewy body disorders with an area under the curve of 0.97 6 0.04, a specificity of 91% (31 of 34), and a sensitivity of 94% (15 of 16). In the validation cohort, 34 patients with PSP (69 years 6 7; 22 women, 12 men), 25 patients with Lewy body disorders (70 years 6 7; nine women, 16 men), and 32 healthy control participants (64 years 6 7; 22 women, 10 men) were evaluated. The accuracy of the FA score was confirmed (area under the curve, 0.96 6 0.04; specificity, 96% [24 of 25]; and sensitivity, 85% [29 of 34]). Conclusion: These cross-validated findings lay the foundation for a clinical test to distinguish progressive supranuclear palsy from Lewy body disorders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Hall, Sarau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-sha
7001 a Irwin, David J.u University of Pennsylvania4 aut
7001 a Rumetshofer, Theodoru Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)th6284ru
7001 a Acosta-Cabronero, Juliou University College London4 aut
7001 a Deik, Andres F.u University of Pennsylvania4 aut
7001 a Spindler, Meredith A.u University of Pennsylvania4 aut
7001 a Lee, Edward B.u University of Pennsylvania4 aut
7001 a Trojanowski, John Q.u University of Pennsylvania4 aut
7001 a Van Westen, Danielleu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups4 aut0 (Swepub:lu)ront-dva
7001 a Nilsson, Markusu Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups4 aut0 (Swepub:lu)med-mun
7001 a Grossman, Murrayu University of Pennsylvania4 aut
7001 a Nestor, Peter J.u University of Queensland4 aut
7001 a McMillan, Corey T.u University of Pennsylvania4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7102 a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
7730 t Radiologyd : Radiological Society of North America (RSNA)g 293:3, s. 646-653q 293:3<646-653x 0033-8419x 1527-1315
8564 u http://dx.doi.org/10.1148/radiol.2019190406y FULLTEXT
8564 u https://pubs.rsna.org/doi/pdf/10.1148/radiol.2019190406
8564 8u https://lup.lub.lu.se/record/8922b8c5-3ca7-459b-b559-d5765325b777
8564 8u https://doi.org/10.1148/radiol.2019190406

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