CSF biomarkers in suicide attempters - a principal component analysis.

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Fältnamn	Indikatorer	Metadata
000		04493naa a2200397 4500
001		oai:lup.lub.lu.se:6e54decf-5cd0-4d3f-8c76-d5c3852b986d
003		SwePub
008		160404s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:122796521
024	7	a https://lup.lub.lu.se/record/17778992 URI
024	7	a https://doi.org/10.1111/j.1600-0447.2010.01655.x2 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1227965212 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Lindqvist, Danielu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-del
245	1 0	a CSF biomarkers in suicide attempters - a principal component analysis.
264		c 2010-12-28
264	1	b Wiley,c 2011
520		a Lindqvist D, Janelidze S, Erhardt S, Träskman-Bendz L, Engström G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug-free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well-defined psychiatric rating scales and followed-up regarding future suicide. We used principal component analysis to identify factors among the biological substances. Results: Four factors were extracted from the 20 biomarkers, explaining 52.4% of the total variance. Factors 1 and 2 were characterized by high loadings of chemokines and cytokines respectively. They were both associated with severe depressive symptoms. Factor 2 was also associated with a high suicidal intent. Factor 4 was characterized by strong loadings of the monoamine metabolites 5-HIAA and HVA, as well as orexin and interleukin-6. High scores on this factor were found in patients who performed a violent suicide attempt and in patients who subsequently completed suicide. Conclusion: Our results suggest that specific combinations of CSF biomarkers may discriminate between types of suicidal behaviour and indicate increased risk for future suicide.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Janelidze, Shorenau Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)nkir-sje
700	1	a Erhardt, Su Karolinska Institutet4 aut
700	1	a Träskman Bendz, Lilu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)psyk-lt8
700	1	a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
700	1	a Brundin, Lenau Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-lla
710	2	a Psykiatri, Lundb Sektion IV4 org
773	0	t Acta Psychiatrica Scandinavicad : Wileyg 124, s. 52-61q 124<52-61x 1600-0447x 0001-690X
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/21198458?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1111/j.1600-0447.2010.01655.xy FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1777899
856	4 8	u https://doi.org/10.1111/j.1600-0447.2010.01655.x
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122796521

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Av författaren/redakt...: Lindqvist, Danie ...; Janelidze, Shore ...; Erhardt, S; Träskman Bendz, ...; Engström, Gunnar; Brundin, Lena

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