Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

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Fältnamn	Indikatorer	Metadata
000		04766naa a2200757 4500
001		oai:lup.lub.lu.se:56517f14-afcd-4156-8088-9082389a74f7
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-227572
024	7	a https://lup.lub.lu.se/record/44702512 URI
024	7	a https://doi.org/10.1177/20474873135165642 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2275722 URI
040		a (SwePub)lud (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Fowkes, F. G. R.4 aut
245	1 0	a Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events
264		c 2013-12-23
264	1	b Oxford University Press (OUP),c 2014
520		a Background The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS + ABI, were fitted for the primary outcome of major coronary events. Results In predicting events in the external validation dataset, C-index for the FRS was 0.672 (95% CI 0.599 to 0.737) in men and 0.578 (95% CI 0.492 to 0.661) in women. The FRS + ABI led to a small increase in C-index in men to 0.685 (95% CI 0.612 to 0.749) and large increase in women to 0.690 (95% CI 0.605 to 0.764) with net reclassification improvement (NRI) of 4.3% (95% CI 0.0 to 7.6%, p = 0.050) and 9.6% (95% CI 6.1 to 16.4%, p < 0.001), respectively. Restricting the FRS + ABI model to those with FRS intermediate 10-year risk of 10 to 19% resulted in higher NRI of 15.9% (95% CI 6.1 to 20.6%, p < 0.001) in men and 23.3% (95% CI 13.8 to 62.5%, p = 0.002) in women. However, incorporating ABI in an improved newly fitted risk factor model had a nonsignificant effect: NRI 2.0% (95% CI 2.3 to 4.2%, p = 0.567) in men and 1.1% (95% CI 1.9 to 4.0%, p = 0.483) in women. Conclusions An ABI risk model may improve prediction especially in individuals at intermediate risk and when performance of the base risk factor model is modest.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Murray, G. D.4 aut
700	1	a Butcher, I.4 aut
700	1	a Folsom, A. R.4 aut
700	1	a Hirsch, A. T.4 aut
700	1	a Couper, D. J.4 aut
700	1	a DeBacker, G.4 aut
700	1	a Kornitzer, M.4 aut
700	1	a Newman, A. B.4 aut
700	1	a Sutton-Tyrrell, K. C.4 aut
700	1	a Cushman, M.4 aut
700	1	a Lee, A. J.4 aut
700	1	a Price, J. F.4 aut
700	1	a D'Agostino Sr., R. B.4 aut
700	1	a Murabito, J. M.4 aut
700	1	a Norman, P. E.4 aut
700	1	a Masaki, K. H.4 aut
700	1	a Bouter, L. M.4 aut
700	1	a Heine, R. J.4 aut
700	1	a Stehouwer, C. D. A.4 aut
700	1	a McDermott, M. M.4 aut
700	1	a Stoffers, H. E. J. H.4 aut
700	1	a Knottnerus, J. A.4 aut
700	1	a Ögren, Matsu Uppsala universitet,Kärlkirurgi4 aut0 (Swepub:uu)matog558
700	1	a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bhe
700	1	a Koenig, W.4 aut
700	1	a Meisinger, C.4 aut
700	1	a Cauley, J. A.4 aut
700	1	a Franco, O. H.4 aut
700	1	a Hunink, M. G. M.4 aut
700	1	a Hofman, A.4 aut
700	1	a Witteman, J. C.4 aut
700	1	a Criqui, M. H.4 aut
700	1	a Langer, R. D.4 aut
700	1	a Hiatt, W. R.4 aut
700	1	a Hamman, R. F.4 aut
710	2	a Uppsala universitetb Kärlkirurgi4 org
773	0	t European Journal of Preventive Cardiologyd : Oxford University Press (OUP)g 21:3, s. 310-320q 21:3<310-320x 2047-4881x 2047-4873
856	4	u http://dx.doi.org/10.1177/2047487313516564y FULLTEXT
856	4	u https://europepmc.org/articles/pmc4685459?pdf=render
856	4 8	u https://lup.lub.lu.se/record/4470251
856	4 8	u https://doi.org/10.1177/2047487313516564
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-227572

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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