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FältnamnIndikatorerMetadata
00007072naa a2200865 4500
001oai:lup.lub.lu.se:4bc2d2f9-cd54-4208-886f-54632a143b8c
003SwePub
008210115s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:145197471
0247 a https://lup.lub.lu.se/record/4bc2d2f9-cd54-4208-886f-54632a143b8c2 URI
0247 a https://doi.org/10.1002/acr.240922 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1451974712 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Barber, Megan R.W.u University of Calgary4 aut
2451 0a Economic Evaluation of Damage Accrual in an International Systemic Lupus Erythematosus Inception Cohort Using a Multistate Model Approach
264 c 2020-11-27
264 1b Wiley,c 2020
300 a 9 s.
520 a Objective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. Annual data on demographics, disease activity, damage (SLICC/American College of Rheumatology Damage Index [SDI]), hospitalizations, medications, dialysis, and selected procedures were collected. Ten-year cumulative costs (Canadian dollars) were estimated by multiplying annual costs associated with each SDI state by the expected state duration using a multistate model. Results: A total of 1,687 patients participated; 88.7% were female, 49.0% were white, mean ± SD age at diagnosis was 34.6 ± 13.3 years, and mean time to follow-up was 8.9 years (range 0.6–18.5 years). Mean annual costs were higher for those with higher SDI scores as follows: $22,006 (Canadian) (95% confidence interval [95% CI] $16,662, $27,350) for SDI scores ≥5 versus $1,833 (95% CI $1,134, $2,532) for SDI scores of 0. Similarly, 10-year cumulative costs were higher for those with higher SDI scores at the beginning of the 10-year interval as follows: $189,073 (Canadian) (95% CI $142,318, $235,827) for SDI scores ≥5 versus $21,713 (95% CI $13,639, $29,788) for SDI scores of 0. Conclusion: Patients with the highest SDI scores incur 10-year cumulative costs that are ~9-fold higher than those with the lowest SDI scores. By estimating the damage trajectory and incorporating annual costs, data on damage can be used to estimate future costs, which is critical knowledge for evaluating the cost-effectiveness of novel therapies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Hanly, John G.u Dalhousie University4 aut
7001 a Su, Liu University of Cambridge4 aut
7001 a Urowitz, Murray B.u University of Toronto4 aut
7001 a St. Pierre, Yvan4 aut
7001 a Romero-Diaz, Juanitau Instituto Nacional de Ciencias Médicas y Nutrición4 aut
7001 a Gordon, Carolineu University of Birmingham4 aut
7001 a Bae, Sang Cheolu Hanyang University4 aut
7001 a Bernatsky, Sashau McGill University Health Center4 aut
7001 a Wallace, Daniel J.u Cedars-Sinai Medical Center4 aut
7001 a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut
7001 a Isenberg, David A.u University College London4 aut
7001 a Rahman, Anisuru University College London4 aut
7001 a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut
7001 a Petri, Michelleu Johns Hopkins University School of Medicine4 aut
7001 a Bruce, Ian N.u Manchester Academic Health Science Centre4 aut
7001 a Dooley, Mary A.u University of North Carolina4 aut
7001 a Fortin, Paul R.u Laval University4 aut
7001 a Gladman, Dafna D.u University of Toronto4 aut
7001 a Sanchez-Guerrero, Jorgeu University of Toronto4 aut
7001 a Steinsson, Kristjanu National University Hospital of Iceland4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University4 aut
7001 a Khamashta, Munther A.4 aut
7001 a Aranow, Cynthiau Feinstein Institutes for Medical Research4 aut
7001 a Mackay, Megganu Feinstein Institutes for Medical Research4 aut
7001 a Alarcón, Graciela S.u University of Alabama4 aut
7001 a Manzi, Susanu University of Pittsburgh4 aut
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo
7001 a Zoma, Asad A.u Hairmyres Hospital4 aut
7001 a van Vollenhoven, Ronald F.u Karolinska Institutet4 aut
7001 a Ramos-Casals, Manuelu Hospital Clínic of Barcelona4 aut
7001 a Ruiz-Irastorza, Guillermou Hospital de Cruces4 aut
7001 a Lim, S. Samu Emory University4 aut
7001 a Kalunian, Kenneth C.u University of California, Los Angeles4 aut
7001 a Inanc, Muratu Istanbul University4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina4 aut
7001 a Peschken, Christine A.u University of Manitoba4 aut
7001 a Jacobsen, Sørenu Copenhagen University Hospital4 aut
7001 a Askanase, Ancau Indian Institute of Technology4 aut
7001 a Farewell, Vernonu University of Cambridge4 aut
7001 a Stoll, Thomas4 aut
7001 a Buyon, Jillu New York University4 aut
7001 a Clarke, Ann E.u University of Calgary4 aut
7102 a University of Calgaryb Dalhousie University4 org
7730 t Arthritis Care and Researchd : Wileyg 72:12, s. 1800-1808q 72:12<1800-1808x 2151-464Xx 2151-4658
8564 u http://dx.doi.org/10.1002/acr.24092y FULLTEXT
8564 u http://pure-oai.bham.ac.uk/ws/files/77244747/Barber_et_al_Economic_evaluation_of_damage_accrual_in_an_international_SLE_inception_cohort_using_a_multi_state_model_approach_Arthritis_Care_Research_2019.pdf
8564 8u https://lup.lub.lu.se/record/4bc2d2f9-cd54-4208-886f-54632a143b8c
8564 8u https://doi.org/10.1002/acr.24092
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145197471

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