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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003207naa a2200397 4500
001oai:DiVA.org:uu-202892
003SwePub
008130701s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2028922 URI
0247 a https://doi.org/10.1016/j.ahj.2013.01.0052 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Giraldez, Roberto R.4 aut
2451 0a Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non-ST-segment elevation acute coronary syndrome
264 1b Elsevier BV,c 2013
338 a print2 rdacarrier
520 a Background We examined the prevalence of undiagnosed diabetes or prediabetes and associations with ischemic outcomes among non-ST-segment elevation acute coronary syndrome (ACS) patients. Methods We categorized 8795 EARLY ACS trial patients into one of the following groups: "known diabetes" (n = 2860 [32.5%]; reported on the case report form), "undiagnosed diabetes" (n = 1069 [12.2%]; no diabetes history and fasting glucose >= 126 mg/dL or hemoglobin A(1c) >= 6.5%), "prediabetes" (n = 947 [10.8%]; fasting glucose >= 110 to <126 mg/dL, or " normal" (n = 3919 [44.5%]). Adjusted associations of known diabetes, undiagnosed diabetes, and prediabetes (versus normal) with 30-day and 1-year outcomes were determined. Results Undiagnosed diabetes was associated with greater 30-day death or myocardial infarction (MI) (ORadj 1.28, 95% CI 1.05-1.57), driven primarily by greater 30-day mortality (ORadj 1.65, 95% CI 1.09-2.48). Known diabetic patients had 30-day death or MI outcomes similar to those of normal patients, but 30-day mortality was higher (ORadj 1.40, 95% CI 1.01-1.93). Prediabetic patients had 30-day death or MI outcomes similar to those of normal patients. One-year mortality was greater among known diabetic patients (HRadj 1.38, 95% CI 1.13-1.67) but not among those with undiagnosed diabetes or prediabetes. Conclusions Undiagnosed diabetes and prediabetes were common among high-risk non-ST-segment elevation ACS patients. Routine screening for undiagnosed diabetes may be useful since these patients seem to have worse short-term outcomes and deserve consideration of alternative management strategies.
7001 a Clare, Robert M.4 aut
7001 a Lopes, Renato D.4 aut
7001 a Dalby, Anthony J.4 aut
7001 a Prabhakaran, Dorairaj4 aut
7001 a Brogan, Gerard X., Jr.4 aut
7001 a Giugliano, Robert P.4 aut
7001 a James, Stefan K.u Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)stjam367
7001 a Tanguay, Jean-Francois4 aut
7001 a Pollack, Charles V., Jr.4 aut
7001 a Harrington, Robert A.4 aut
7001 a Braunwald, Eugene4 aut
7001 a Newby, L. Kristin4 aut
7102 a Uppsala universitetb Kardiologi4 org
7730 t American Heart Journald : Elsevier BVg 165:6, s. 918-925.e2q 165:6<918-925.e2x 0002-8703x 1097-6744
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202892
8564 8u https://doi.org/10.1016/j.ahj.2013.01.005

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