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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003722naa a2200421 4500
001oai:gup.ub.gu.se/306401
003SwePub
008240528s2022 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3064012 URI
0247 a https://doi.org/10.1007/s00415-021-10678-42 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Broman, J.4 aut
2451 0a Initiation of antidepressants in young adults after ischemic stroke: a registry-based follow-up study
264 c 2021-06-24
264 1b Springer Science and Business Media LLC,c 2022
520 a Objective: Data on post-stroke use of antidepressants in young individuals are scarce. We examined pattern and factors associated with initiating post-stroke antidepressants (PSAD) after ischemic stroke (IS) in young adults. Methods: Helsinki Young Stroke Registry includes patients aged 15–49years with first-ever IS, 1994–2007. Data on prescriptions, hospitalizations and death came from nationwide registers. We defined time of initiating PSAD as time of the first filled prescription for antidepressants within 1year from IS. We assessed factors associated with initiating PSAD with multivariable Cox regression models, allowing for time-varying effects when appropriate. Results: We followed 888 patients, of which 206 (23.2%) initiated PSAD. Higher hazard of starting PSAD within the first 100days appeared among patients with mild versus no limb paresis 2.53 (95% confidence interval 1.48–4.31) and during later follow-up among those with silent infarcts (2.04; 1.27–3.28), prior use of antidepressants (2.09; 1.26–3.46) and moderate versus mild stroke (2.06; 1.18–3.58). The relative difference in the hazard rate for moderate–severe limb paresis persisted both within the first 100days (3.84, 2.12–6.97) and during later follow-up (4.54; 2.51–8.23). The hazard rate was higher throughout the follow-up among smokers (1.48; 1.11–1.97) as well as lower (1.78; 1.25–2.54) and upper white-collar workers (2.00; 1.24–3.23) compared to blue-collar workers. Conclusion: One-fourth of young adults started PSADs within 1year from IS. We identified several specific clinical characteristics associated with PSAD initiation, highlighting their utility in assessing the risk of post-stroke depression during follow-up. © 2021, The Author(s).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Antidepressants
653 a Brain infarction
653 a Stroke
653 a Young adult
7001 a Aarnio, K.4 aut
7001 a But, A.4 aut
7001 a Marinkovic, I.4 aut
7001 a Rodríguez-Pardo, J.4 aut
7001 a Kaste, M.4 aut
7001 a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt
7001 a Putaala, J.4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org
7730 t Journal of Neurologyd : Springer Science and Business Media LLCg 269, s. 956-965q 269<956-965x 0340-5354x 1432-1459
8564 u https://link.springer.com/content/pdf/10.1007/s00415-021-10678-4.pdf
8564 8u https://gup.ub.gu.se/publication/306401
8564 8u https://doi.org/10.1007/s00415-021-10678-4

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