The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load: A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls

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Södergren, AnnaUmeå universitet,Reumatologi (författare)

The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load : A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls

Artikel/kapitelEngelska2015

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2015-04-15
The Journal of Rheumatology,2015
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LIBRIS-ID:oai:DiVA.org:umu-106500
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106500URI
https://doi.org/10.3899/jrheum.140694DOI

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Språk:engelska
Sammanfattning på:engelska

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Objective. This prospective followup study investigated subclinical atherosclerosis in relation to traditional cardiovascular disease (CVD) risk factors and inflammation in patients with rheumatoid arthritis (RA) recruited at diagnosis compared with controls. Methods. Patients diagnosed with early RA were consecutively recruited into a prospective study. From these, a subgroup aged <= 60 years (n = 71) was consecutively included for ultrasound measurement of intima-media thickness (IMT) and flow-mediated dilation (FMD) at inclusion (T0) and after 5 years (T5). Age-and sex-matched controls (n = 40) were also included. Results. In the Wilcoxon signed-rank test, both IMT and FMD were significantly aggravated at T5 compared to baseline in patients with RA, whereas only IMT was significantly increased in controls. In univariate linear regression analyses among patients with RA, the IMT at T5 was significantly associated with age, systolic blood pressure (BP), cholesterol, triglycerides, Systematic Coronary Risk Evaluation (SCORE), and Reynolds Risk Score at baseline (p < 0.05). Similarly, FMD at T5 was significantly inversely associated with age, smoking, systolic BP, SCORE, and Reynolds Risk Score (p < 0.05). A model with standardized predictive value from multiple linear regression models including age, smoking, BP, and blood lipids at baseline significantly predicted the observed value of IMT after 5 years. When also including the area under the curve for the 28-joint Disease Activity Score over 5 years, the observed value of IMT was predicted to a large extent. Conclusion. This prospective study identified an increased subclinical atherosclerosis in patients with RA. In the patients with RA, several traditional CVD risk factors at baseline significantly predicted the extent of subclinical atherosclerosis 5 years later. The inflammatory load over time augmented this prediction.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
Rheumatoid Arthritis
Cardiovascular Disease
Inflammation
Atherosclerosis
Prospective

Biuppslag (personer, institutioner, konferenser, titlar ...)

Karp, KjellUmeå universitet,Klinisk fysiologi(Swepub:umu)kjka0001 (författare)
Bengtsson, Christine (författare)
Moller, Bozena (författare)
Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi (författare)
Wållberg-Jonsson, SolveigUmeå universitet,Reumatologi(Swepub:umu)sowa0001 (författare)
Umeå universitetReumatologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Rheumatology: The Journal of Rheumatology42:6, s. 935-9420315-162X1499-2752

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Av författaren/redakt...: Södergren, Anna; Karp, Kjell; Bengtsson, Chris ...; Moller, Bozena; Rantapää-Dahlqvi ...; Wållberg-Jonsson ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

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Av lärosätet: Umeå universitet

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