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What underlies the diversity of brain tumors?
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- Swartling, Fredrik J., 1975- (author)
- Uppsala universitet,Cancer och vaskulärbiologi,Swartling
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- Hede, Sanna-Maria, 1975- (author)
- Uppsala universitet,Cancer och vaskulärbiologi,Swartling
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- Weiss, William A., 1960- (author)
- Dept. of Neurology, University of California, San Francisco,Weiss
- (creator_code:org_t)
- 2012-10-21
- 2013
- English.
- In: Cancer Metastasis Review. - : Springer. - 0167-7659 .- 1573-7233. ; 32:1-2 (SI), s. 5-24
- Research review (peer-reviewed)
Abstract
Subject headings
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- Glioma and medulloblastoma represent the most commonly occurring malignant brain tumors in adults and in children, respectively. Recent genomic and transcriptional approaches present a complex group of diseases and delineate a number of molecular subgroups within tumors that share a common histopathology. Differences in cells of origin, regional niches, developmental timing, and genetic events all contribute to this heterogeneity. In an attempt to recapitulate the diversity of brain tumors, an increasing array of genetically engineered mouse models (GEMMs) has been developed. These models often utilize promoters and genetic drivers from normal brain development and can provide insight into specific cells from which these tumors originate. GEMMs show promise in both developmental biology and developmental therapeutics. This review describes numerous murine brain tumor models in the context of normal brain development and the potential for these animals to impact brain tumor research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Development
- Medulloblastoma
- Glioma
- Murine model
- Transgene
- Oncology
- Onkologi
- Biology with specialization in Molecular Cell Biology
- Biologi med inriktning mot molekylär cellbiologi
- Experimentell patologi
- Experimental Pathology
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