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Molecular packing s...
Molecular packing structure of fibrin fibers resolved by X-ray scattering and molecular modeling
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- Jansen, Karin A. (författare)
- AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;UMC Utrecht, Dept Pathol, NL-3508 GA Utrecht, Netherlands.
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- Zhmurov, Artem (författare)
- KTH,Parallelldatorcentrum, PDC,Sechenov Univ, Moscow 119991, Russia.
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- Vos, Bart E. (författare)
- AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Univ Munster, Ctr Mol Biol Inflammat, Inst Cell Biol, Munster, Germany.
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- Portale, Giuseppe (författare)
- Univ Groningen, Zernike Inst Adv Mat, Macromol Chem & New Polymer Mat, Nijenborgh 4, NL-9747 AG Groningen, Netherlands.
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- Hermida-Merino, Daniel (författare)
- ESRF, DUBBLE CRG, Netherlands Org Sci Res NWO, 71 Ave Martyrs, F-38000 Grenoble, France.
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- Litvinov, Rustem, I (författare)
- Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.;Kazan Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia.
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- Tutwiler, Valerie (författare)
- Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.
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- Kurniawan, Nicholas A. (författare)
- AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands.;Eindhoven Univ Technol, Inst Complex Mol Syst, Eindhoven, Netherlands.
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- Bras, Wim (författare)
- ESRF, DUBBLE CRG, Netherlands Org Sci Res NWO, 71 Ave Martyrs, F-38000 Grenoble, France.;Oak Ridge Natl Lab, Chem Sci Div, One Bethel Valley Rd, Oak Ridge, TN 37831 USA.
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- Weisel, John W. (författare)
- Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.
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- Barsegov, Valeri (författare)
- Univ Massachusetts, Dept Chem, 1 Univ Ave, Lowell, MA 01854 USA.
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- Koenderink, Gijsje H. (författare)
- AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands.;Delft Univ Technol, Kavli Inst Nanosci Delft, Dept Bionanosci, Maasweg 9, NL-2629 HZ Delft, Netherlands.
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AMOLF, Biol Soft Matter Grp, Utrecht, Netherlands;UMC Utrecht, Dept Pathol, NL-3508 GA Utrecht, Netherlands. Parallelldatorcentrum, PDC (creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-683X .- 1744-6848. ; 16:35, s. 8272-8283
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.rsc.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Fibrin is the major extracellular component of blood clots and a proteinaceous hydrogel used as a versatile biomaterial. Fibrin forms branched networks built of laterally associated double-stranded protofibrils. This multiscale hierarchical structure is crucial for the extraordinary mechanical resilience of blood clots, yet the structural basis of clot mechanical properties remains largely unclear due, in part, to the unresolved molecular packing of fibrin fibers. Here the packing structure of fibrin fibers is quantitatively assessed by combining Small Angle X-ray Scattering (SAXS) measurements of fibrin reconstituted under a wide range of conditions with computational molecular modeling of fibrin protofibrils. The number, positions, and intensities of the Bragg peaks observed in the SAXS experiments were reproduced computationally based on the all-atom molecular structure of reconstructed fibrin protofibrils. Specifically, the model correctly predicts the intensities of the reflections of the 22.5 nm axial repeat, corresponding to the half-staggered longitudinal arrangement of fibrin molecules. In addition, the SAXS measurements showed that protofibrils within fibrin fibers have a partially ordered lateral arrangement with a characteristic transverse repeat distance of 13 nm, irrespective of the fiber thickness. These findings provide fundamental insights into the molecular structure of fibrin clots that underlies their biological and physical properties.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Jansen, Karin A.
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Zhmurov, Artem
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Vos, Bart E.
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Portale, Giusepp ...
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Hermida-Merino, ...
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Litvinov, Rustem ...
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visa fler...
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Tutwiler, Valeri ...
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Kurniawan, Nicho ...
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Bras, Wim
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Weisel, John W.
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Barsegov, Valeri
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Koenderink, Gijs ...
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Soft Matter
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