Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(White Victoria) > Genetic Variants Re...

LIBRIS Formathandbok (Information om MARC21)

Details
MARC

Fältnamn	Indikatorer	Metadata
000		09079naa a2201777 4500
001		oai:DiVA.org:uu-337237
003		SwePub
008		171221s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-142908
009		oai:prod.swepub.kib.ki.se:136760620
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3372372 URI
024	7	a https://doi.org/10.1016/j.eururo.2017.07.0152 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1429082 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1367606202 URI
040		a (SwePub)uud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Machiela, Mitchell J4 aut
245	1 0	a Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.
264	1	b Elsevier BV,c 2017
338		a print2 rdacarrier
500		a Correction in: European Urology, Vol. 74, Issue 3, pages e85-e86DOI: 10.1016/j.eururo.2018.05.017
500		a Correction to affiliations for authors Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, and Cezary Cybulski in a corrected list, DOI: 10.1016/j.eururo.2018.05.017
520		a BACKGROUND: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.OBJECTIVE: We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk using Mendelian randomization, an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations.DESIGN, SETTING, AND PARTICIPANTS: Genotypes from nine telomere length-associated variants for 10 784 cases and 20 406 cancer-free controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) relating the GRS and RCC risk were computed in individual GWAS datasets and combined by meta-analysis.RESULTS AND LIMITATIONS: Longer genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07 per predicted kilobase increase, 95% confidence interval [CI]:=1.70-2.53, p<0.0001). As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R2>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001). Exploratory analyses for individual histologic subtypes suggested comparable associations with the telomere length GRS for clear cell (N=5573, OR=1.93, 95% CI=1.50-2.49, p<0.0001), papillary (N=573, OR=1.96, 95% CI=1.01-3.81, p=0.046), and chromophobe RCC (N=203, OR=2.37, 95% CI=0.78-7.17, p=0.13).CONCLUSIONS: Our investigation adds to the growing body of evidence indicating some aspect of longer telomere length is important for RCC risk.PATIENT SUMMARY: Telomeres are segments of DNA at chromosome ends that maintain chromosomal stability. Our study investigated the relationship between genetic variants associated with telomere length and renal cell carcinoma risk. We found evidence suggesting individuals with inherited predisposition to longer telomere length are at increased risk of developing renal cell carcinoma.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653		a Genetic variants
653		a Mendelian randomization
653		a Renal cell carcinoma
653		a Risk
653		a Telomere length
700	1	a Hofmann, Jonathan N4 aut
700	1	a Carreras-Torres, Robert4 aut
700	1	a Brown, Kevin M4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Foll, Matthieu4 aut
700	1	a Li, Peng4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Savage, Sharon A4 aut
700	1	a Gaborieau, Valerie4 aut
700	1	a McKay, James D4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Henrion, Marc4 aut
700	1	a Bruinsma, Fiona4 aut
700	1	a Jordan, Susan4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Vatten, Lars J4 aut
700	1	a Fletcher, Tony4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Larsson, Susanna Cu Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)susla720
700	1	a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516
700	1	a Banks, Rosamonde E4 aut
700	1	a Selby, Peter J4 aut
700	1	a Easton, Douglas F4 aut
700	1	a Pharoah, Paul4 aut
700	1	a Andreotti, Gabriella4 aut
700	1	a Freeman, Laura E Beane4 aut
700	1	a Koutros, Stella4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Clark, Peter E4 aut
700	1	a Edwards, Todd E4 aut
700	1	a Lipworth, Loren4 aut
700	1	a Gapstur, Susan M4 aut
700	1	a Stevens, Victoria L4 aut
700	1	a Carol, Hallie4 aut
700	1	a Freedman, Matthew L4 aut
700	1	a Pomerantz, Mark M4 aut
700	1	a Cho, Eunyoung4 aut
700	1	a Kraft, Peter4 aut
700	1	a Preston, Mark A4 aut
700	1	a Wilson, Kathryn M4 aut
700	1	a Gaziano, J Michael4 aut
700	1	a Sesso, Howard S4 aut
700	1	a Black, Amanda4 aut
700	1	a Freedman, Neal D4 aut
700	1	a Huang, Wen-Yi4 aut
700	1	a Anema, John G4 aut
700	1	a Kahnoski, Richard J4 aut
700	1	a Lane, Brian R4 aut
700	1	a Noyes, Sabrina L4 aut
700	1	a Petillo, David4 aut
700	1	a Colli, Leandro M4 aut
700	1	a Sampson, Joshua N4 aut
700	1	a Besse, Celine4 aut
700	1	a Blanche, Helene4 aut
700	1	a Boland, Anne4 aut
700	1	a Burdette, Laurie4 aut
700	1	a Prokhortchouk, Egor4 aut
700	1	a Skryabin, Konstantin G4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Mijuskovic, Mirjana4 aut
700	1	a Ognjanovic, Miodrag4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Mates, Dana4 aut
700	1	a Mukeriya, Anush4 aut
700	1	a Rascu, Stefan4 aut
700	1	a Zaridze, David4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Cybulski, Cezary4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Jinga, Viorel4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Navratilova, Marie4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Szeszenia-Dabrowska, Neonila4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Bueno-de-Mesquita, H Bas4 aut
700	1	a Canzian, Federico4 aut
700	1	a Duell, Eric J4 aut
700	1	a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
700	1	a Sitaram, Raviprakash T.u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)tura0001
700	1	a Peters, Ulrike4 aut
700	1	a White, Emily4 aut
700	1	a Anderson, Garnet L4 aut
700	1	a Johnson, Lisa4 aut
700	1	a Luo, Juhua4 aut
700	1	a Buring, Julie4 aut
700	1	a Lee, I-Min4 aut
700	1	a Chow, Wong-Ho4 aut
700	1	a Moore, Lee E4 aut
700	1	a Wood, Christopher4 aut
700	1	a Eisen, Timothy4 aut
700	1	a Larkin, James4 aut
700	1	a Choueiri, Toni K4 aut
700	1	a Lathrop, G Mark4 aut
700	1	a Teh, Bin Tean4 aut
700	1	a Deleuze, Jean-Francois4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Houlston, Richard S4 aut
700	1	a Brennan, Paul4 aut
700	1	a Chanock, Stephen J4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Purdue, Mark P4 aut
710	2	a Uppsala universitetb Ortopedi4 org
773	0	t European Urologyd : Elsevier BVg 72:5, s. 747-754q 72:5<747-754x 0302-2838x 1873-7560
856	4	u http://eprints.whiterose.ac.uk/119343/26/Supplementary%20Materials_Revision3_clean.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337237
856	4 8	u https://doi.org/10.1016/j.eururo.2017.07.015
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142908
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:136760620

Find in a library

European Urology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Machiela, Mitche ...; Hofmann, Jonatha ...; Carreras-Torres, ...; Brown, Kevin M; Johansson, Matti ...; Wang, Zhaoming; show more...; Foll, Matthieu; Li, Peng; Rothman, Nathani ...; Savage, Sharon A; Gaborieau, Valer ...; McKay, James D; Ye, Yuanqing; Henrion, Marc; Bruinsma, Fiona; Jordan, Susan; Severi, Gianluca; Hveem, Kristian; Vatten, Lars J; Fletcher, Tony; Koppova, Kvetosl ...; Larsson, Susanna ...; Wolk, Alicja; Banks, Rosamonde ...; Selby, Peter J; Easton, Douglas ...; Pharoah, Paul; Andreotti, Gabri ...; Freeman, Laura E ...; Koutros, Stella; Albanes, Demetri ...; Mannisto, Satu; Weinstein, Steph ...; Clark, Peter E; Edwards, Todd E; Lipworth, Loren; Gapstur, Susan M; Stevens, Victori ...; Carol, Hallie; Freedman, Matthe ...; Pomerantz, Mark ...; Cho, Eunyoung; Kraft, Peter; Preston, Mark A; Wilson, Kathryn ...; Gaziano, J Micha ...; Sesso, Howard S; Black, Amanda; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richar ...; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Colli, Leandro M; Sampson, Joshua ...; Besse, Celine; Blanche, Helene; Boland, Anne; Burdette, Laurie; Prokhortchouk, E ...; Skryabin, Konsta ...; Yeager, Meredith; Mijuskovic, Mirj ...; Ognjanovic, Miod ...; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleon ...; Jinga, Viorel; Lissowska, Jolan ...; Lubinski, Jan; Navratilova, Mar ...; Rudnai, Peter; Szeszenia-Dabrow ...; Benhamou, Simone; Cancel-Tassin, G ...; Cussenot, Olivie ...; Bueno-de-Mesquit ...; Canzian, Federic ...; Duell, Eric J; Ljungberg, Börje; Sitaram, Ravipra ...; Peters, Ulrike; White, Emily; Anderson, Garnet ...; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E; Wood, Christophe ...; Eisen, Timothy; Larkin, James; Choueiri, Toni K; Lathrop, G Mark; Teh, Bin Tean; Deleuze, Jean-Fr ...; Wu, Xifeng; Houlston, Richar ...; Brennan, Paul; Chanock, Stephen ...; Scelo, Ghislaine; Purdue, Mark P; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

Articles in the publication: European Urology

By the university: Uppsala University; Umeå University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se