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  • Stenström, PatrikKTH,Fiber- och polymerteknologi (författare)

Synthesis and in Vitro Evaluation of Monodisperse Amino-Functional Polyester Dendrimers with Rapid Degradability and Antibacterial Properties

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-11-22
  • American Chemical Society (ACS),2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-221021
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-221021URI
  • https://doi.org/10.1021/acs.biomac.7b01364DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137342661URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20180112
  • Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons, including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs and siRNA, and simple functionalization in aqueous solutions. Dendrimers, a subclass of precision polymers, are monodisperse and exhibit a large and exact number of peripheral end groups in relation to their size and have shown promise in drug delivery, biomedical imaging and as antiviral agents. In this work, hydroxyl functional dendrimers of generation 1 to 5 based on 2,2-bis(methylol)propionic acid (bis-MPA) were modified to bear 6 to 96 peripheral amino groups through esterification reactions with beta-alanine. All dendrimers were isolated in high yields and with remarkable monodispersity. This was successfully accomplished utilizing the present advantages of fluoride-promoted esterification (FPE) with imidazole-activated monomers. Straightforward postfunctionalization was conducted on a second generation amino functional dendrimer with tetraethylene glycol through NHS-amidation and carbonyl diimidazole (CDI) activation to full conversion with short reaction times. Fast biodegradation of the dendrimers through loss of peripheral beta-alanine groups was observed and generational- and dose-dependent cytotoxicity was evaluated with a set of cell lines. An increase. in neurotoxicity compared to hydroxyl-functional dendrimers was shown in neuronal cells, however, the dendrimers were slightly less neurotoxic than commercially available poly(amidoamine) dendrimers (PAMAMs). Additionally, their effect on bacteria was evaluated and the second generation dendrimer was found unique inhibiting the growth of Escherichia coli at physiological conditions while being nontoxic toward human cells. Finally, these results cement a robust and sustainable synthetic route to amino-functional polyester dendrimers with interesting chemical and biological properties.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hjorth, ErikKarolinska Institutet (författare)
  • Zhang, YuningKTH,Ytbehandlingsteknik(Swepub:kth)u1bh78yi (författare)
  • Andrén, Oliver C. J.KTH,Ytbehandlingsteknik(Swepub:kth)u1fshusr (författare)
  • Guette-Marquet, Simon (författare)
  • Schultzberg, MarianneKarolinska Institutet (författare)
  • Malkoch, Michael,1974-KTH,Fiber- och polymerteknologi(Swepub:kth)u18z6ljf (författare)
  • KTHFiber- och polymerteknologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biomacromolecules: American Chemical Society (ACS)18:12, s. 4323-43301525-77971526-4602

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