A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

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Fältnamn	Indikatorer	Metadata
000		06921naa a2201381 4500
001		oai:DiVA.org:uu-453372
003		SwePub
008		210916s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:147597035
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4533722 URI
024	7	a https://doi.org/10.1002/hbm.256252 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475970352 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gutman, Boris A4 aut
245	1 0	a A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
264		c 2021-09-08
264	1	b John Wiley & Sons,c 2022
338		a print2 rdacarrier
520		a Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a schizophrenia
653		a structure
653		a subcortical shape
700	1	a van Erp, Theo G M4 aut
700	1	a Alpert, Kathryn4 aut
700	1	a Ching, Christopher R K4 aut
700	1	a Isaev, Dmitry4 aut
700	1	a Ragothaman, Anjani4 aut
700	1	a Jahanshad, Neda4 aut
700	1	a Saremi, Arvin4 aut
700	1	a Zavaliangos-Petropulu, Artemis4 aut
700	1	a Glahn, David C4 aut
700	1	a Shen, Li4 aut
700	1	a Cong, Shan4 aut
700	1	a Alnaes, Dag4 aut
700	1	a Andreassen, Ole Andreas4 aut
700	1	a Doan, Nhat Trung4 aut
700	1	a Westlye, Lars T4 aut
700	1	a Kochunov, Peter4 aut
700	1	a Satterthwaite, Theodore D4 aut
700	1	a Wolf, Daniel H4 aut
700	1	a Huang, Alexander J4 aut
700	1	a Kessler, Charles4 aut
700	1	a Weideman, Andrea4 aut
700	1	a Nguyen, Dana4 aut
700	1	a Mueller, Bryon A4 aut
700	1	a Faziola, Lawrence4 aut
700	1	a Potkin, Steven G4 aut
700	1	a Preda, Adrian4 aut
700	1	a Mathalon, Daniel H4 aut
700	1	a Bustillo, Juan4 aut
700	1	a Calhoun, Vince4 aut
700	1	a Ford, Judith M4 aut
700	1	a Walton, Esther4 aut
700	1	a Ehrlich, Stefan4 aut
700	1	a Ducci, Giuseppe4 aut
700	1	a Banaj, Nerisa4 aut
700	1	a Piras, Fabrizio4 aut
700	1	a Piras, Federica4 aut
700	1	a Spalletta, Gianfranco4 aut
700	1	a Canales-Rodríguez, Erick J4 aut
700	1	a Fuentes-Claramonte, Paola4 aut
700	1	a Pomarol-Clotet, Edith4 aut
700	1	a Radua, Joaquim4 aut
700	1	a Salvador, Raymond4 aut
700	1	a Sarró, Salvadoru Karolinska Institutet4 aut
700	1	a Dickie, Erin W4 aut
700	1	a Voineskos, Aristotle4 aut
700	1	a Tordesillas-Gutiérrez, Diana4 aut
700	1	a Crespo-Facorro, Benedicto4 aut
700	1	a Setién-Suero, Esther4 aut
700	1	a van Son, Jacqueline Mayoral4 aut
700	1	a Borgwardt, Stefan4 aut
700	1	a Schönborn-Harrisberger, Fabienne4 aut
700	1	a Morris, Derek4 aut
700	1	a Donohoe, Gary4 aut
700	1	a Holleran, Laurena4 aut
700	1	a Cannon, Dara4 aut
700	1	a McDonald, Colmu Karolinska Institutet4 aut
700	1	a Corvin, Aiden4 aut
700	1	a Gill, Michael4 aut
700	1	a Filho, Geraldo Busatto4 aut
700	1	a Rosa, Pedro G P4 aut
700	1	a Serpa, Mauricio H4 aut
700	1	a Zanetti, Marcus V4 aut
700	1	a Lebedeva, Irina4 aut
700	1	a Kaleda, Vasily4 aut
700	1	a Tomyshev, Alexander4 aut
700	1	a Crow, Tim4 aut
700	1	a James, Anthony4 aut
700	1	a Cervenka, Simon4 aut
700	1	a Sellgren, Carl M4 aut
700	1	a Fatouros-Bergman, Helenau Karolinska Institutet4 aut
700	1	a Agartz, Ingridu Karolinska Institutet4 aut
700	1	a Howells, Fleur4 aut
700	1	a Stein, Dan J4 aut
700	1	a Temmingh, Henk4 aut
700	1	a Uhlmann, Anne4 aut
700	1	a de Zubicaray, Greig I4 aut
700	1	a McMahon, Katie L4 aut
700	1	a Wright, Margie4 aut
700	1	a Cobia, Derin4 aut
700	1	a Csernansky, John G4 aut
700	1	a Thompson, Paul M4 aut
700	1	a Turner, Jessica A4 aut
700	1	a Wang, Lei4 aut
710	2	a Karolinska Institutet4 org
773	0	t Human Brain Mappingd : John Wiley & Sonsg 43:1, s. 352-372q 43:1<352-372x 1065-9471x 1097-0193
856	4	u https://doi.org/10.1002/hbm.25625y Fulltext
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25625
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453372
856	4 8	u https://doi.org/10.1002/hbm.25625
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:147597035

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Av författaren/redakt...: Gutman, Boris A; van Erp, Theo G ...; Alpert, Kathryn; Ching, Christoph ...; Isaev, Dmitry; Ragothaman, Anja ...; visa fler...; Jahanshad, Neda; Saremi, Arvin; Zavaliangos-Petr ...; Glahn, David C; Shen, Li; Cong, Shan; Alnaes, Dag; Andreassen, Ole ...; Doan, Nhat Trung; Westlye, Lars T; Kochunov, Peter; Satterthwaite, T ...; Wolf, Daniel H; Huang, Alexander ...; Kessler, Charles; Weideman, Andrea; Nguyen, Dana; Mueller, Bryon A; Faziola, Lawrenc ...; Potkin, Steven G; Preda, Adrian; Mathalon, Daniel ...; Bustillo, Juan; Calhoun, Vince; Ford, Judith M; Walton, Esther; Ehrlich, Stefan; Ducci, Giuseppe; Banaj, Nerisa; Piras, Fabrizio; Piras, Federica; Spalletta, Gianf ...; Canales-Rodrígue ...; Fuentes-Claramon ...; Pomarol-Clotet, ...; Radua, Joaquim; Salvador, Raymon ...; Sarró, Salvador; Dickie, Erin W; Voineskos, Arist ...; Tordesillas-Guti ...; Crespo-Facorro, ...; Setién-Suero, Es ...; van Son, Jacquel ...; Borgwardt, Stefa ...; Schönborn-Harris ...; Morris, Derek; Donohoe, Gary; Holleran, Lauren ...; Cannon, Dara; McDonald, Colm; Corvin, Aiden; Gill, Michael; Filho, Geraldo B ...; Rosa, Pedro G P; Serpa, Mauricio ...; Zanetti, Marcus ...; Lebedeva, Irina; Kaleda, Vasily; Tomyshev, Alexan ...; Crow, Tim; James, Anthony; Cervenka, Simon; Sellgren, Carl M; Fatouros-Bergman ...; Agartz, Ingrid; Howells, Fleur; Stein, Dan J; Temmingh, Henk; Uhlmann, Anne; de Zubicaray, Gr ...; McMahon, Katie L; Wright, Margie; Cobia, Derin; Csernansky, John ...; Thompson, Paul M; Turner, Jessica ...; Wang, Lei; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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