Gestational age at birth and risk of testicular cancer

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Fältnamn	Indikatorer	Metadata
000		03705naa a2200409 4500
001		oai:lup.lub.lu.se:28b417bc-cd78-41d8-a937-89228ee0befc
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/27995542 URI
024	7	a https://doi.org/10.1002/ijc.263712 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Crump, Casey4 aut
245	1 0	a Gestational age at birth and risk of testicular cancer
264		c 2011-09-14
264	1	b Wiley,c 2012
520		a Most testicular germ cell tumors originate from carcinoma in situ cells in fetal life, possibly related to sex hormone imbalances in early pregnancy. Previous studies of association between gestational age at birth and testicular cancer have yielded discrepant results and have not examined extreme preterm birth. Our objective was to determine whether low gestational age at birth is independently associated with testicular cancer in later life. We conducted a national cohort study of 354,860 men born in Sweden in 19731979, including 19,214 born preterm (gestational age < 37 weeks) of whom 1,279 were born extremely preterm (2229 weeks), followed for testicular cancer incidence through 2008. A total of 767 testicular cancers (296 seminomas and 471 nonseminomatous germ cell tumors) were identified in 11.2 million person-years of follow-up. Extreme preterm birth was associated with an increased risk of testicular cancer (hazard ratio = 3.95; 95% confidence interval = 1.679.34) after adjusting for other perinatal factors, family history of testicular cancer and cryptorchidism. Only five cases (three seminomas and two nonseminomas) occurred among men born extremely preterm, limiting the precision of risk estimates. No association was found between later preterm birth, post-term birth or low or high fetal growth and testicular cancer. These findings suggest that extreme but not later preterm birth may be independently associated with testicular cancer in later life. They are based on a small number of cases and will need confirmation in other large cohorts. Elucidation of the key prenatal etiologic factors may potentially lead to preventive interventions in early life.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a gestational age
653		a premature birth
653		a nonseminomatous germ cell tumor
653		a seminoma
653		a testicular neoplasms
700	1	a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ksq
700	1	a Winkleby, Marilyn A.4 aut
700	1	a Sieh, Weiva4 aut
700	1	a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsu
710	2	a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t International Journal of Cancerd : Wileyg 131:2, s. 446-451q 131:2<446-451x 0020-7136
856	4	u http://dx.doi.org/10.1002/ijc.26371y FULLTEXT
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.26371
856	4 8	u https://lup.lub.lu.se/record/2799554
856	4 8	u https://doi.org/10.1002/ijc.26371

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Av författaren/redakt...: Crump, Casey; Sundquist, Krist ...; Winkleby, Marily ...; Sieh, Weiva; Sundquist, Jan

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: International Jo ...

Av lärosätet: Lunds universitet

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