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- Habuka, MasatoKTH,Science for Life Laboratory, SciLifeLab,Karolinska University Hospital, Sweden (author)
The Kidney Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-12-31
- Public Library of Science (PLoS),2014
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-159369
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159369URI
- https://doi.org/10.1371/journal.pone.0116125DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:130417282URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242861URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20150130
- To understand renal functions and disease, it is important to define the molecular constituents of the various compartments of the kidney. Here, we used comparative transcriptomic analysis of all major organs and tissues in the human body, in combination with kidney tissue micro array based immunohistochemistry, to generate a comprehensive description of the kidney-specific transcriptome and proteome. A special emphasis was placed on the identification of genes and proteins that were elevated in specific kidney subcompartments. Our analysis identified close to 400 genes that had elevated expression in the kidney, as compared to the other analysed tissues, and these were further subdivided, depending on expression levels, into tissue enriched, group enriched or tissue enhanced. Immunohistochemistry allowed us to identify proteins with distinct localisation to the glomeruli (n=11), proximal tubules (n=120), distal tubules (n=9) or collecting ducts (n=8). Among the identified kidney elevated transcripts, we found several proteins not previously characterised or identified as elevated in kidney. This description of the kidney specific transcriptome and proteome provides a resource for basic and clinical research to facilitate studies to understand kidney biology and disease.
Subject headings and genre
- NATURVETENSKAP Biologi Annan biologi hsv//swe
- NATURAL SCIENCES Biological Sciences Other Biological Topics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- Alpha-Crystallin
- Slit Diaphragm
- Rna-Seq
- Gene
- Nephrin
- Expression
- Disease
- Biology
- Tool
- Uromodulin
Added entries (persons, corporate bodies, meetings, titles ...)
- Fagerberg, LinnKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dglfid (author)
- Hallström, Björn M.KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ih19oh (author)
- Kampf, CarolineUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)carokamp (author)
- Edlund, KarolinaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)kaedl086 (author)
- Sivertsson, ÅsaKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u195d5b0 (author)
- Yamamoto, Tadashi (author)
- Pontén, FredrikUppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)fredpont (author)
- Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw (author)
- Odeberg, JacobKarolinska Institutet,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,Karolinska University Hospital, Sweden(Swepub:kth)u1e4yljo (author)
- KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science (PLoS)9:12, s. e116125-1932-6203
Internet link
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116125&type=printable
- https://uu.diva-portal.org/smash/get/diva2:786120/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159369
- https://doi.org/10.1371/journal.pone.0116125
- http://kipublications.ki.se/Default.aspx?queryparsed=id:130417282
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242861
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