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Sökning: WFRF:(Hallström Björn) > The Kidney Transcri...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05004naa a2200649 4500 | |
| 001 | oai:DiVA.org:kth-159369 | |
| 003 | SwePub | |
| 008 | 150129s2014 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:130417282 | |
| 009 | oai:DiVA.org:uu-242861 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1593692 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.01161252 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1304172822 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2428612 URI |
| 040 | a (SwePub)kthd (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Habuka, Masatou KTH,Science for Life Laboratory, SciLifeLab,Karolinska University Hospital, Sweden4 aut0 (Swepub:kth)u14p536i |
| 245 | 1 0 | a The Kidney Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling |
| 264 | c 2014-12-31 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2014 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20150130 | |
| 520 | a To understand renal functions and disease, it is important to define the molecular constituents of the various compartments of the kidney. Here, we used comparative transcriptomic analysis of all major organs and tissues in the human body, in combination with kidney tissue micro array based immunohistochemistry, to generate a comprehensive description of the kidney-specific transcriptome and proteome. A special emphasis was placed on the identification of genes and proteins that were elevated in specific kidney subcompartments. Our analysis identified close to 400 genes that had elevated expression in the kidney, as compared to the other analysed tissues, and these were further subdivided, depending on expression levels, into tissue enriched, group enriched or tissue enhanced. Immunohistochemistry allowed us to identify proteins with distinct localisation to the glomeruli (n=11), proximal tubules (n=120), distal tubules (n=9) or collecting ducts (n=8). Among the identified kidney elevated transcripts, we found several proteins not previously characterised or identified as elevated in kidney. This description of the kidney specific transcriptome and proteome provides a resource for basic and clinical research to facilitate studies to understand kidney biology and disease. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Annan biologi0 (SwePub)106992 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Other Biological Topics0 (SwePub)106992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
| 653 | a Alpha-Crystallin | |
| 653 | a Slit Diaphragm | |
| 653 | a Rna-Seq | |
| 653 | a Gene | |
| 653 | a Nephrin | |
| 653 | a Expression | |
| 653 | a Disease | |
| 653 | a Biology | |
| 653 | a Tool | |
| 653 | a Uromodulin | |
| 700 | 1 | a Fagerberg, Linnu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dglfid |
| 700 | 1 | a Hallström, Björn M.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ih19oh |
| 700 | 1 | a Kampf, Carolineu Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)carokamp |
| 700 | 1 | a Edlund, Karolinau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)kaedl086 |
| 700 | 1 | a Sivertsson, Åsau KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u195d5b0 |
| 700 | 1 | a Yamamoto, Tadashi4 aut |
| 700 | 1 | a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fredpont |
| 700 | 1 | a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw |
| 700 | 1 | a Odeberg, Jacobu Karolinska Institutet,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,Karolinska University Hospital, Sweden4 aut0 (Swepub:kth)u1e4yljo |
| 710 | 2 | a KTHb Science for Life Laboratory, SciLifeLab4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 9:12, s. e116125-q 9:12<e116125-x 1932-6203 |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116125&type=printable |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:786120/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159369 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0116125 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130417282 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242861 |
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