Intestinal circulation, oxygenation and metabolism is not affected by oleic acid lung injury.

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Fältnamn	Indikatorer	Metadata
000		03948naa a2200481 4500
001		oai:DiVA.org:umu-6033
003		SwePub
008		071218s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60332 URI
024	7	a https://doi.org/10.1111/j.1475-097X.2005.00640.x2 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Claesson, Jonasu Umeå universitet,Anestesiologi och intensivvård4 aut
245	1 0	a Intestinal circulation, oxygenation and metabolism is not affected by oleic acid lung injury.
264	1	c 2005
338		a electronic2 rdacarrier
520		a This study was performed to establish a platform for further studies on effects of ventilatory treatment modalities on the intestines during mechanical ventilation of acute lung injury (ALI). We tested the hypotheses that oleic acid (OA) infusion causes changes in intestinal circulation, oxygenation and metabolism, and that OA is distributed to tissues outside the lung. This was performed as an experimental, prospective and controlled study in an university animal research laboratory. Thirteen juvenile anaesthetized pigs were used in the main study, where seven were given an intravenous infusion of 0.1 ml kg(-1) OA and six served as control (surgery only). In a separate study, four animals were given an intravenous infusion of 0.1 ml kg(-1) (3)H-labelled OA. We measured systemic and mesenteric (portal venous blood flow, jejunal mucosal perfusion) haemodynamic parameters, mesenteric oxygenation (jejunal tissue oxygen tension) and systemic cytokines (tumour necrosis factor-alpha and interleukin-6). We calculated mesenteric lactate flux and mesenteric oxygen delivery, uptake and extraction ratio. In the animals given 3H-OA, we measured 3H-OA in different tissues (lungs, heart, liver, kidney, stomach, jejunum, colon and arterial blood). We found that OA given intravenously is distributed in small amounts to the intestines. This intestinal exposure to OA does not cause intestinal injury when evaluating mesenteric blood flow, metabolism or oxygenation. OA infusion induced a moderate increase in mean pulmonary arterial pressure and a decrease in PaO2/Fraction inspired O2 (P/F) ratio, giving evidence of severe lung injury. Consequently, the OA lung injury model is suitable for studies on intestinal effects of ventilatory treatment modalities during mechanical ventilation of ALI.
653		a Animals
653		a Disease Models; Animal
653		a Female
653		a Injections; Intravenous
653		a Intestines/blood supply/drug effects/physiopathology
653		a Metabolic Clearance Rate
653		a Oleic Acid/administration & dosage/pharmacokinetics
653		a Oxygen/*metabolism
653		a Respiratory Distress Syndrome; Adult/chemically induced/*physiopathology
653		a Swine
653		a Tissue Distribution
700	1	a Lehtipalo, Stefanu Umeå universitet,Anestesiologi och intensivvård4 aut0 (Swepub:umu)stnleo96
700	1	a Bergstrand, Ulfu Umeå universitet,Anestesiologi och intensivvård4 aut
700	1	a Arnerlöv, Connyu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)coar0003
700	1	a Rocksen, David4 aut
700	1	a Hultin, Magnus4 aut
700	1	a Winsö, Ola4 aut
710	2	a Umeå universitetb Anestesiologi och intensivvård4 org
773	0	t Clinical Physiology and Functional Imagingg 25:6, s. 357-363q 25:6<357-363x 1475-0961x 1475-097X
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16268988&dopt=Citation
856	4	u https://umu.diva-portal.org/smash/get/diva2:145701/FULLTEXT01.pdfx primaryx Raw objecty fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6033
856	4 8	u https://doi.org/10.1111/j.1475-097X.2005.00640.x

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Av författaren/redakt...: Claesson, Jonas; Lehtipalo, Stefa ...; Bergstrand, Ulf; Arnerlöv, Conny; Rocksen, David; Hultin, Magnus; visa fler...; Winsö, Ola; visa färre...

Artiklar i publikationen: Clinical Physiol ...

Av lärosätet: Umeå universitet

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