Advances in genome-scale metabolic models of industrially important fungi

Many fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved predictions of cell states and proteome allocation. Here, we provide an overview of these newly developed GEMs and computational methods that facilitate construction of enzyme-constrained GEMs and utilize flux predictions from GEMs. Furthermore, we highlight the pivotal roles of these GEMs in iterative design–build–test–learn cycles, ultimately advancing the field of fungal biomanufacturing.

Tafur Rangel, Albert Enrique,1992Chalmers tekniska högskola,Chalmers University of Technology,Novo Nordisk Fonden,Novo Nordisk Foundation(Swepub:cth)tafur (författare)
Pomraning, Kyle R.Pacific Northwest National Laboratory (författare)
Kerkhoven, Eduard,1985Science for Life Laboratory (SciLifeLab),Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)eduardk (författare)
Kim, JoonhoonPacific Northwest National Laboratory,United States Department of Energy (författare)
Pacific Northwest National LaboratoryChalmers tekniska högskola (creator_code:org_t)

Av författaren/redakt...: Han, Yichao; Tafur Rangel, Al ...; Pomraning, Kyle ...; Kerkhoven, Eduar ...; Kim, Joonhoon

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