SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Martínez J. Alfredo)
 

Sökning: WFRF:(Martínez J. Alfredo) > TFAP2B-dietary prot...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003520naa a2200397 4500
001oai:DiVA.org:umu-82641
003SwePub
008131105s2013 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-826412 URI
024a https://doi.org/10.1159/0003535912 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Stocks, Tanjau Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)taasts96
2451 0a TFAP2B-dietary protein and glycemic index interactions and weight maintenance after weight loss in the DiOGenes trial
264 c 2013-09-27
264 1b S. Karger AG,c 2013
338 a print2 rdacarrier
520 a Background: TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has an effect on weight loss. We investigated interactions between rs987237 and protein-to-carbohydrate ratio or glycemic index (GI) in relation to weight maintenance after weight loss.Methods: This study included 742 obese individuals from 8 European countries who participated in the Diet, Obesity, and Genes (DiOGenes) trial, lost >= 8% of their initial body weight during an 8-week low-calorie diet and were randomized to one of 5 ad libitum diets with a fixed energy percentage from fat: either low-protein/low-GI, low-protein/high-GI, high-protein/low-GI, or high-protein/high-GI diets, or a control diet for a 6-month weight maintenance period. Using linear regression analyses and additive genetic models, we investigated main and dietary interaction effects of TFAP2B rs987237 in relation to weight maintenance.Results: In total, 468 completers of the trial were genotyped for rs987237. High-protein diets were beneficial for weight maintenance in the AA genotype group (67% of participants), but in the AG and GG groups no differences were observed for low- or high-protein diets. On the high-protein diet, carriers of the obesity risk allele (G allele) regained 1.84 kg (95% CI: 0.02; 3.67, p = 0.047) more body weight per risk allele than individuals on a low-protein diet. There was no interaction effect between rs987237 and GI on weight maintenance.Conclusion: TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance. Considering the carbohydrate proportion of the diet, the interaction was different from the previously reported rs987237-fat-to-carbohydrate ratio interaction for weight loss. Thus, TFAP2B-macronutrient interactions might diverge depending on the nutritional state.(C) 2013 S. Karger AG, Basel
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700a Ängquist, Lars4 aut
700a Hager, Joerg4 aut
700a Charon, Celine4 aut
700a Hoist, Claus4 aut
700a Martinez, J Alfredo4 aut
700a Saris, Wim HM4 aut
700a Astrup, Arne4 aut
700a Sorensen, Thorkild IA4 aut
700a Larsen, Lesli H4 aut
710a Umeå universitetb Urologi och andrologi4 org
773t Human Heredityd : S. Karger AGg 75:2-4, s. 213-219q 75:2-4<213-219x 0001-5652x 1423-0062
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82641
8564 8u https://doi.org/10.1159/000353591

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy