Osteoprotegerin and osteocalcin are associated with atherosclerosis in patients with rheumatoid arthritis: a prospective cohort study

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Fältnamn	Indikatorer	Metadata
000		03535naa a2200373 4500
001		oai:DiVA.org:umu-158061
003		SwePub
008		190412s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1580612 URI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wahlin, Bengtu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)betwan97
245	1 0	a Osteoprotegerin and osteocalcin are associated with atherosclerosis in patients with rheumatoid arthritis :b a prospective cohort study
264	1	c 2021
338		a print2 rdacarrier
500		a Previously included in thesis in manuscript form.
520		a OBJECTIVES:Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aim of this study was to examine the associations between subclinical atherosclerosis, assessed by intima-media thickness (IMT), and regulators of bone formation, markers of bone turnover and bone mineral density (BMD) in patients with RA.METHODS:Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were consecutively included in a study of development of atherosclerosis. Ultrasound measurement of IMT of the common carotid artery was undertaken at inclusion (T0) and after 11 years (T11) (n=54). Bone turnover biomarkers were examined in samples collected at T0 and T11. BMD was assessed at T11.RESULTS:In patients with RA, osteocalcin (OCN) and osteoprotegerin (OPG) measured at T11 were significantly associated with IMT at T11, adjusted for systolic blood pressure (SBP) and age. BMD at T11 and the bone turnover markers procollagen type 1 N-terminal propeptide (P1NP) and carboxy-terminal crosslinked C-terminal telopeptide (CTX) were not associated with IMT. OPG, OCN and sclerostin at T0 were significantly associated with IMT at T11, and OPG and OCN at T0 were associated with change in IMT from T0 to T11. The associations between IMT and bone biomarkers were stronger in patients with joint erosions at onset of RA, than in patients with non-erosive disease.CONCLUSIONS:Atherosclerosis in patients with RA is associated with OPG and OCN, but not with BMD or markers reflecting ongoing bone turnover, indicating that atherosclerosis is not associated with bone turnover per se.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a rheumatoid arthritis
653		a atherosclerosis
653		a osteoporosis
653		a bone remodelling
700	1	a Ramnemark, Annau Umeå universitet,Geriatrik4 aut0 (Swepub:umu)anra0067
700	1	a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
700	1	a Wållberg-Jonsson, Solveig,d 1953-u Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
700	1	a Södergren, Anna,d 1977-u Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)4 aut0 (Swepub:umu)anayxt97
710	2	a Umeå universitetb Reumatologi4 org
773	0	t Clinical and Experimental Rheumatologyg 39:6, s. 1402-1409q 39:6<1402-1409x 0392-856Xx 1593-098X
856	4	u https://www.clinexprheumatol.org/abstract.asp?a=16340y URL (Publiser's full text)
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158061

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Av författaren/redakt...: Wahlin, Bengt; Ramnemark, Anna; Rantapää-Dahlqvi ...; Wållberg-Jonsson ...; Södergren, Anna, ...

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