Modeling of the Effect of Alcohol on Episode Patterns in Atrial Fibrillation

Growing evidence shows that alcohol triggers paroxysmal atrial fibrillation (PAF) in some patients. How-ever, there is a lack of methods for assessing the causality between triggers and atrial fibrillation (AF) episodes. Accordingly, this work aims to develop an approach to episode modeling under the influence of alcohol for the purpose of evaluating causality assessment methods. The alternating, bivariate Hawkes model is used to produce episode patterns, where the conditional intensity function λ1(t) defines the transitions from sinus rhythm (SR) to AF. The effect of alcohol consumption is characterized by a body reactivity function, defined by the base intensity μ1(t), which alters λ1(t). Different AF episode patterns were modeled for alcohol units ranging from 0 to 15. The mean AF burden without alcohol was 17.2%, which doubled with 9 alcohol units; the number of AF episodes doubled from 12.9 with 8 alcohol units. The aggregation of AF episodes tended to decrease after 6 alcohol units. The proposed model of alcohol-affected PAF patterns may be useful for assessing the methods for evaluation of causality between triggers and PAF occurrence.

Rapalis, AndriusKaunas University of Technology (författare)
Butkuviene, MonikaKaunas University of Technology (författare)
Marozas, VaidotasKaunas University of Technology (författare)
Sornmo, LeifLund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Teknik för hälsa,LTH profilområden,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH(Swepub:lu)tde-lso (författare)
Petrenas, AndriusKaunas University of Technology (författare)
Kaunas University of TechnologyAvdelningen för Biomedicinsk teknik (creator_code:org_t)

Ingår i:2022 Computing in Cardiology, CinC 20222022-September2325-887X2325-88619798350300970

Av författaren/redakt...: Plusciauskaite, ...; Rapalis, Andrius; Butkuviene, Moni ...; Marozas, Vaidota ...; Sornmo, Leif; Petrenas, Andriu ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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