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Sökning: WFRF:(Warensjö Lemming Eva) > Long-term dietary v...

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FältnamnIndikatorerMetadata
00004415naa a2200505 4500
001oai:DiVA.org:uu-159833
003SwePub
008111010s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:124710901
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1598332 URI
024a https://doi.org/10.1016/j.bone.2012.02.1822 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1247109012 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Snellman, Greta,d 1978-u Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)gresn966
2451 0a Long-term dietary vitamin D intake and risk of fracture and osteoporosis :b a longitudinal cohort study of Swedish middle-aged and elderly women
264 1b Elsevier BV,c 2012
338 a print2 rdacarrier
500 a Also published in the same volume of Bone on pages S136-S137 with DOI 10.1016/j.bone.2012.02.421
520 a Context: Vitamin D deficiency may lead to osteoporosis and fracture but the importance of dietary vitamin D intake for skeletal health in adults is uncertain.Objective: To investigate associations between long-term dietary intake of vitamin D with risk of fractures and osteoporosis.Design: A prospective longitudinal cohort study.Setting: The population-based Swedish Mammography Cohort and the subcohort SMC Clinical.Participants: 61,433 women (age range 38 to 76 years) were followed for 19 years. Of these, 5,022 participated in the subcohort. Diet was assessed by repeated food frequency questionnaires.   Main outcome measures: Incident fractures of any type and hip fractures, which were identified from registry data. Secondary outcome was osteoporosis diagnosed by dual energy x ray absorptiometry in the subcohort.Results: 14,738 women experienced any type of first fracture during follow-up, with 3,871 of these being hip fractures. Twenty percent of the women in the subcohort were classified as osteoporotic. A multivariable-adjusted hazard ratio (HR) and 95% confidence interval (CI) for any first fracture was 0.96 (95% CI 0.92-1.01) for the lowest and 1.02 (95% CI 0.96-1.07) for the highest quintile when compared with the third quintile of vitamin D intake. The corresponding HR for a first hip fracture was 1.02 (95% CI, 0.96-1.08) for the lowest and 1.14 (95% CI, 1.03-1.26) for the highest quintile. The odds ratio of osteoporosis by quintiles of vitamin D intake was 1.20 (95% CI, 0.85-1.71) for the lowest and 0.99 (95% CI, 0.78-1.25) for the highest quintile. Bone mineral density, however, were 2% higher at the lumbar spine and 0.3% higher at the total hip in women with highest vs. women with lowest intake of vitamin D (p<0.0001). Conclusions: Dietary intake of vitamin D seems to be of minor importance for the occurrence of fractures and osteoporosis in community-dwelling Swedish middle-aged and elderly women.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653 a Vitamin D
653 a fraktur
653 a BMD
653 a observationsstudie
653 a Epidemiologi
653 a Epidemiology
653 a Orthopaedics
653 a Ortopedi
700a Byberg, Liisau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)liisbybe
700a Warensjö-Lemming, Evau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)evwar172
700a Melhus, Håkanu Uppsala universitet,Klinisk farmakologi4 aut0 (Swepub:uu)hakamelh
700a Gedeborg, Rolfu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)rolfgede
700a Mallmin, Hansu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)hansmall
700a Wolk, Alicjau Institutet för miljömedicin, Karolinska Institutet4 aut
700a Michaëlsson, Karlu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich
710a Uppsala universitetb Ortopedi4 org
773t Boned : Elsevier BVg 50:Suppl 1, s. S65-S65q 50:Suppl 1<S65-S65x 8756-3282x 1873-2763
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159833
8564 8u https://doi.org/10.1016/j.bone.2012.02.182
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124710901

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