Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task

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Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task

Xin, D. L. (author): Department of Surgery, University of Pennsylvania, USA

Hadrevi, Jenny (author): Umeå universitet,Yrkes- och miljömedicin

Elliott, M. E. (author): Department of Neurosurgery, Thomas Jefferson University, USA

Amin, M (author): Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadephia, USA

Harris, M. Y. (author): Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, USA

Barr-Gillespie, A (author): College of Health Professions, Pacific University, USA

Barbe, M. F. (author): Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, USA

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2017-03-29
2017
English.
In: BMC Neuroscience. - : BioMed Central. - 1471-2202. ; 18

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://bmcneurosci....; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury (rats perform an upper extremity reaching task for prolonged periods). Here, we sought to determine if sickness behaviors are induced in this model and the effectiveness of conservative treatments.Methods: Experimental rats underwent initial training to learn a high force reaching task (10 min/day, 5 days/week for 6 weeks), with or without ibuprofen treatment (TRHF vs. TRHF + IBU rats). Subsets of trained animals went on to perform a high repetition high force (HRHF) task for 6 or 12 weeks (2 h/day, 3 days/week) without treatment, or received two secondary interventions: ibuprofen (HRHF + IBU) or a move to a lower demand low repetition low force task (HRHF-to-LRLF), beginning in task week 5. Mixed-effects models with repeated measures assays were used to assay duration of social interaction, aggression, forepaw withdrawal thresholds and reach performance abilities. One-way and two-way ANOVAs were used to assay tissue responses. Corrections for multiple comparisons were made.Results: TRHF + IBU rats did not develop behavioral declines or systemic increases in IL-1beta and IL-6, observed in untreated TRHF rats. Untreated HRHF rats showed social interaction declines, difficulties performing the operant task and forepaw mechanical allodynia. Untreated HRHF rats also had increased serum levels of several inflammatory cytokines and chemokines, neuroinflammatory responses (e.g., increased TNFalpha) in the brain, median nerve and spinal cord, and Substance P and neurokinin 1 immunoexpression in the spinal cord. HRHF + IBU and HRHF-to-LRLF rats showed improved social interaction and reduced inflammatory serum, nerve and brain changes. However, neither secondary treatment rescued HRHF-task induced forepaw allodynia, or completely attenuated task performance declines or spinal cord responses.Conclusions: These results suggest that inflammatory mechanisms induced by prolonged performance of high physical demand tasks mediate the development of social interaction declines and aggression. However, persistent spinal cord sensitization was associated with persistent behavioral indices of discomfort, despite use of conservative secondary interventions indicating the need for prevention or more effective interventions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)

Keyword

Repetitive loading
Work-related musculoskeletal disorders
Upper extremity
Social interaction
Aggression
Mechanical hypersensitivity
Von Frey
Inflammation
Cytokines
neurologi
Neurology

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art (subject category)

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By the author/editor: Xin, D. L.; Hadrevi, Jenny; Elliott, M. E.; Amin, M; Harris, M. Y.; Barr-Gillespie, ...; show more...; Barbe, M. F.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Social and Clini ...

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By the university: Umeå University

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