Sökning: L773:1872 7913 > PER extended-spectr...
Fältnamn | Indikatorer | Metadata |
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000 | 03195naa a2200397 4500 | |
001 | oai:research.chalmers.se:66d424b2-240a-4a30-bd4e-f0ff2c1a8548 | |
003 | SwePub | |
008 | 200329s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://research.chalmers.se/publication/5162172 URI |
024 | 7 | a https://doi.org/10.1016/j.ijantimicag.2018.10.0192 DOI |
040 | a (SwePub)cth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ebmeyer, Stefanu Göteborgs universitet,University of Gothenburg4 aut |
245 | 1 0 | a PER extended-spectrum β-lactamases originate from Pararheinheimera spp |
264 | 1 | b Elsevier BV,c 2019 |
520 | a To investigate the origin of PER extended-spectrum β-lactamases, publicly available sequence databases were searched for bla PER-like genes. Three genomes from Pararheinheimera, a genus associated with water and soil environments, were found to carry bla PER-like genes but lacked the ISCR1/ISPa12/ISPa13 insertion sequences commonly associated with bla PER in clinical isolates. Sequence analysis revealed 78–96% nucleotide identity and conserved synteny between the clinical mobile genetic elements (MGEs) encoding bla PER-1 and the bla PER locus in the Pararheinheimera genomes. Notably, bla PER genes were only identified in 3 of 21 Pararheinheimera and Rheinheimera genomes, whereas the genetic environment of bla PER genes as found in clinical MGEs was conserved in all Pararheinheimera and Rheinheimera genomes. These findings indicate that bla PER genes were likely acquired by a branch of the Pararheinheimera genus long before the antibiotic era. Later, bla PER genes were mobilised, likely through the involvement of insertion sequences, from one or several Pararheinheimera species, allowing their dissemination into human pathogens. | |
650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
653 | a Antimicrobial resistance | |
653 | a Extended-spectrum β-lactamase | |
653 | a ESBL | |
653 | a PER-1 | |
653 | a Pararheinheimera | |
700 | 1 | a Kristiansson, Erik,d 1978u Chalmers tekniska högskola,Chalmers University of Technology,Göteborgs universitet,University of Gothenburg4 aut0 (Swepub:cth)erikkr |
700 | 1 | a Larsson, D. G. Joakim,d 1969u Göteborgs universitet,University of Gothenburg4 aut |
710 | 2 | a Göteborgs universitetb Chalmers tekniska högskola4 org |
773 | 0 | t International Journal of Antimicrobial Agentsd : Elsevier BVg 53:2, s. 158-164q 53:2<158-164x 1872-7913x 0924-8579 |
856 | 4 8 | u https://research.chalmers.se/publication/516217 |
856 | 4 8 | u https://doi.org/10.1016/j.ijantimicag.2018.10.019 |
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