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Low serum levels of...
Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden : Relations with season, age, ethnic origin and psychiatric diagnosis
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- Humble, Mats B., 1952- (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset,Department of Clinical Neuroscience, Division of Psychiatry, St. Göran, Karolinska Institutet, Stockholm, Sweden
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- Gustafsson, Sven (författare)
- Karolinska Institutet
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- Bejerot, Susanne, 1955- (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Oxford, United Kingdom : Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Journal of Steroid Biochemistry and Molecular Biology. - Oxford, United Kingdom : Elsevier BV. - 0960-0760 .- 1879-1220. ; 121:1-2, s. 467-470
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In a chart review at a psychiatric out-patient department, latitude 59.3 degrees N, a sample of patients with tests of serum 25-hydroxy-vitamin D (25-OHD) and plasma intact parathyroid hormone (iPTH) was collected, together with demographic data and psychiatric diagnoses. During 19 months, 117 patients were included. Their median 25-0HD was 45 nmol/l; considerably lower than published reports on Swedish healthy populations. Only 14.5% had recommended levels (over 75). In 56.4%, 25-OHD was under 50 nmol/l, which is related to several unfavourable health outcomes. Seasonal variation of 25-OHD was blunted. Patients with ADHD had unexpectedly low iPTH levels. Middle East, South-East Asian or African ethnic origin, being a young male and having a diagnosis of autism spectrum disorder or schizophrenia predicted low 25-OHD levels. Hence, the diagnoses that have been hypothetically linked to developmental (prenatal) vitamin D deficiency, schizophrenia and autism, had the lowest 25-OHD levels in this adult sample, supporting the notion that vitamin D deficiency may not only be a predisposing developmental factor but also relate to the adult patients' psychiatric state. This is further supported by the considerable psychiatric improvement that coincided with vitamin D treatment in some of the patients whose deficiency was treated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Vitamin D
- Calcidiol
- Parathyroid hormone
- Blood levels
- Out-patients
- Chart review
- Autism
- Schizophrenia
- Bipolar disorder
- Depressive disorder
- ADHD
- Ethnic groups
- Immigrants
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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