Sökning: WFRF:(Agarwal Prasoon) > Integrative Analysi...
Fältnamn | Indikatorer | Metadata |
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000 | 03212naa a2200445 4500 | |
001 | oai:DiVA.org:kth-305109 | |
003 | SwePub | |
008 | 211122s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3051092 URI |
024 | 7 | a https://doi.org/10.3390/cells101027652 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Warrier, Neerada Meenakshiu Manipal Acad Higher Educ, Manipal Inst Technol, Dept Biotechnol, Manipal 576104, Karnataka, India.4 aut |
245 | 1 0 | a Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma |
264 | c 2021-10-15 | |
264 | 1 | b MDPI AG,c 2021 |
338 | a print2 rdacarrier | |
500 | a QC 20211122 | |
520 | a It is imperative to identify the mechanisms that confer stemness to the cancer cells for more effective targeting. Moreover, there are not many studies on the link between stemness characteristics and the immune response in tumours. Therefore, in the current study involving GBM, we started with the study of BIRC5 (one of the rare genes differentially expressed in normal and cancer cells) and CXCR4 (gene involved in the survival and proliferation of CSCs). Together, these genes have not been systematically explored. We used a set of 27 promoter methylated regions in GBM. Our analysis showed that four genes corresponding to these regions, namely EOMES, BDNF, HLA-A, and PECAM1, were involved with BIRC5 and CXCR4. Interestingly, we found EOMES to be very significantly involved in stemness and immunology and it was positively correlated to CXCR4. Additionally, BDNF, which was significant in methylation, was negatively correlated to BIRC5. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a integrative analysis | |
653 | a network analysis | |
653 | a DNA methylation | |
653 | a stemness | |
653 | a immune infiltration | |
653 | a GBM | |
700 | 1 | a Agarwal, Prasoonu KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1w12f9s |
700 | 1 | a Kumar, Praveenu Manipal Acad Higher Educ, Manipal Inst Technol, Dept Biotechnol, Manipal 576104, Karnataka, India.4 aut |
710 | 2 | a Manipal Acad Higher Educ, Manipal Inst Technol, Dept Biotechnol, Manipal 576104, Karnataka, India.b Beräkningsvetenskap och beräkningsteknik (CST)4 org |
773 | 0 | t Cellsd : MDPI AGg 10:10q 10:10x 2073-4409 |
856 | 4 | u https://doi.org/10.3390/cells10102765y Fulltext |
856 | 4 | u https://www.mdpi.com/2073-4409/10/10/2765/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305109 |
856 | 4 8 | u https://doi.org/10.3390/cells10102765 |
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