Systemic cytokines are elevated in a subset of patients with irritable bowel syndrome but largely unrelated to symptom characteristics

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Fältnamn	Indikatorer	Metadata
000		04644naa a2200553 4500
001		oai:gup.ub.gu.se/272050
003		SwePub
008		240528s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2720502 URI
024	7	a https://doi.org/10.1111/nmo.133782 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bennet, Seanu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut
245	1 0	a Systemic cytokines are elevated in a subset of patients with irritable bowel syndrome but largely unrelated to symptom characteristics
264		c 2018-05-24
264	1	b Wiley,c 2018
520		a BackgroundSerum levels of pro-inflammatory cytokines tend to be increased in irritable bowel syndrome (IBS) patients, or subgroups thereof. Still, the link between cytokine levels and IBS symptoms is unclear. We aim to determine systemic cytokine levels in IBS patients and healthy subjects (HS), confirm the presence of a subset of patients with an increased immune activity and to establish if cytokines are linked to IBS symptoms and pathophysiological factors. MethodsSerum levels of interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor (TNF), and IL-10 were measured. All subjects reported IBS symptoms using validated questionnaires and underwent colonic sensorimotor testing. Multivariate supervised orthogonal partial least squares-discriminant analysis (OPLS-DA) and unsupervised principal component analysis (PCA) and hierarchical cluster analysis (HCA) were implemented. Key ResultsIrritable bowel syndrome patients (n=246) had higher serum levels of IL-1, IL-6, IL-8, TNF, and IL-10 compared to HS (n=21); however, serum cytokine profiles could not discriminate patients from HS. Moreover, cytokine levels were not correlated with symptoms among patients. Supervised OPLS-DA identified 104 patients (40% of patients) and unsupervised HCA analysis identified 49 patients (20%) with an increased immune activity indicated by elevated levels of serum cytokines compared to HS and the other patients. However, irrespective of how patients with increased immune activity were identified they were symptomatically similar to patients with no indication of increased immune activity. Conclusions & InferencesSerum cytokines are elevated in IBS patients compared to HS. Immune activation characterizes a subset of patients, but modest associations between cytokine profile and symptoms suggest immune activity does not directly influence symptoms in IBS.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653		a cytokines
653		a IBS
653		a symptom
653		a functional gastrointestinal disorders
653		a placebo-controlled trial
653		a quality-of-life
653		a immune activation
653		a gut microbiota
653		a mast-cells
653		a ibs
653		a validation
653		a disease
653		a questionnaire
653		a Gastroenterology & Hepatology
653		a Neurosciences & Neurology
700	1	a Palsson, O.4 aut
700	1	a Whitehead, W. E.4 aut
700	1	a Barrow, D. A.4 aut
700	1	a Törnblom, Hans,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xtornh
700	1	a Öhman, Lena,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Biomedicine, Department of Microbiology and Immunology,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohmal
700	1	a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xsimrm
700	1	a van Tilburg, M. A. L.4 aut
710	2	a Göteborgs universitetb Institutionen för medicin4 org
773	0	t Neurogastroenterology and Motilityd : Wileyg 30:10q 30:10x 1350-1925x 1365-2982
856	4	u https://cdr.lib.unc.edu/downloads/pn89dd08t
856	4 8	u https://gup.ub.gu.se/publication/272050
856	4 8	u https://doi.org/10.1111/nmo.13378

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Av författaren/redakt...: Bennet, Sean; Palsson, O.; Whitehead, W. E.; Barrow, D. A.; Törnblom, Hans, ...; Öhman, Lena, 196 ...; visa fler...; Simrén, Magnus, ...; van Tilburg, M. ...; visa färre...

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Av lärosätet: Göteborgs universitet

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