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Quality control of ...
Quality control of flow cytometry data analysis for evaluation of minimal residual disease in bone marrow from acute leukemia patients during treatment.
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- Björklund, Elisabet (författare)
- Department of Pathology and Cytology, Karolinska University Hospital, Solna, Sweden
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- Matinlauri, Irma (författare)
- Department of Clinical Chemistry and Hematology, Kuopio University Hospital, Kuopio, Finland
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- Tierens, Anne (författare)
- Department of Pathology, Rikshospitalet-Radiumhospitalet-HF, Oslo, Norway
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- Axelsson, Susanne, 1976- (författare)
- Department of Pathology, Örebro University Hospital (USÖ), Örebro, Sweden
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- Forestier, Erik (författare)
- Umeå universitet,Pediatrik,Department of Pathology and Cytology, University Hospital Umeå, Sweden
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- Jacobsson, Stefan, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Laboratory of Clinical Chemistry Sahlgrenska/SU, Göteborg, Sweden
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- Ahlberg, Asa Jeppsson (författare)
- Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Karolinska Institute, Stockholm, Sweden
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- Kauric, Goran (författare)
- Department of Immunology, Transfusion Medicine University Hospital of North Norway, Tromsö, Norway
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- Mäntymaa, Pentti (författare)
- entre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
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- Osnes, Liv (författare)
- Department of Immunology and Transfusion Medicine, Ullevål University Hospital, Norway
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- Penttilä, Tarja-Leena (författare)
- Department of Immunology and Transfusion Medicine, TYKSLAB, Turku University Hospital, Turku, Finland
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- Marquart, Hanne (författare)
- Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
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- Savolainen, Eeva-Riitta (författare)
- Department of Hematology, Hematology Laboratory, Oulu University Hospital, Finland
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- Siitonen, Sanna (författare)
- Department of Clinical Chemistry and Hematology, HUSLAB, Helsinki University Hospital, Helsinki, Finland
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- Torikka, Kerstin (författare)
- ICH-laboratory Blood Center, Lund University Hospital, Lund, Sweden
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- Mazur, Joanna (författare)
- Department of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland
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- Porwit, Anna (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2009
- 2009
- Engelska.
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Ingår i: Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. - : Lippincott Williams & Wilkins. - 1536-3678 .- 1077-4114. ; 31:6, s. 406-15
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Low levels of leukemia cells in the bone marrow, minimal residual disease (MRD), are considered to be a powerful indicator of treatment response in acute lymphatic leukemia (ALL). A Nordic quality assurance program, aimed on standardization of the flow cytometry MRD analysis, has been established before implementation of MRD at cutoff level 10 as one of stratifying parameters in next Nordic Society of Pediatric Hematology and Oncology (NOPHO) treatment program for ALL. In 4 quality control (QC) rounds 15 laboratories determined the MRD levels in 48 follow-up samples from 12 ALL patients treated according to NOPHO 2000. Analysis procedures were standardized. For each QC round a compact disc containing data in list-mode files was sent out and results were submitted to a central laboratory. At cutoff level 10, which will be applied for clinical decisions, laboratories obtained a high concordance (91.6%). If cutoff level 10 was applied, the concordance would be lower (85.3%). The continuing standardization resulted in better concordance in QC3 and QC4 compared with QC1 and QC2. The concordance was higher in precursor B as compared with T-cell ALL. We conclude that after standardization, flow cytometry MRD detection can be reliably applied in international, multicenter treatment protocols.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Adolescent
- Bone Marrow
- pathology
- Bone Marrow Examination
- standards
- Child
- Child
- Preschool
- Female
- Flow Cytometry
- standards
- Humans
- Male
- Medical Oncology
- standards
- Middle Aged
- Neoplasm
- Residual
- diagnosis
- Pathology
- Clinical
- standards
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- diagnosis
- Quality Control
- standardization
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Björklund, Elisa ...
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Matinlauri, Irma
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Tierens, Anne
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Axelsson, Susann ...
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Forestier, Erik
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Jacobsson, Stefa ...
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Ahlberg, Asa Jep ...
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Kauric, Goran
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Mäntymaa, Pentti
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Osnes, Liv
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Penttilä, Tarja- ...
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Marquart, Hanne
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Savolainen, Eeva ...
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Siitonen, Sanna
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Torikka, Kerstin
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Mazur, Joanna
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Porwit, Anna
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Journal of pedia ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Örebro universitet
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Karolinska Institutet