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  • Björklund, ElisabetDepartment of Pathology and Cytology, Karolinska University Hospital, Solna, Sweden (author)

Quality control of flow cytometry data analysis for evaluation of minimal residual disease in bone marrow from acute leukemia patients during treatment.

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2009

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/104564
  • https://gup.ub.gu.se/publication/104564URI
  • https://doi.org/10.1097/MPH.0b013e3181a1c0e8DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34976URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110578URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118866843URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Low levels of leukemia cells in the bone marrow, minimal residual disease (MRD), are considered to be a powerful indicator of treatment response in acute lymphatic leukemia (ALL). A Nordic quality assurance program, aimed on standardization of the flow cytometry MRD analysis, has been established before implementation of MRD at cutoff level 10 as one of stratifying parameters in next Nordic Society of Pediatric Hematology and Oncology (NOPHO) treatment program for ALL. In 4 quality control (QC) rounds 15 laboratories determined the MRD levels in 48 follow-up samples from 12 ALL patients treated according to NOPHO 2000. Analysis procedures were standardized. For each QC round a compact disc containing data in list-mode files was sent out and results were submitted to a central laboratory. At cutoff level 10, which will be applied for clinical decisions, laboratories obtained a high concordance (91.6%). If cutoff level 10 was applied, the concordance would be lower (85.3%). The continuing standardization resulted in better concordance in QC3 and QC4 compared with QC1 and QC2. The concordance was higher in precursor B as compared with T-cell ALL. We conclude that after standardization, flow cytometry MRD detection can be reliably applied in international, multicenter treatment protocols.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Matinlauri, IrmaDepartment of Clinical Chemistry and Hematology, Kuopio University Hospital, Kuopio, Finland (author)
  • Tierens, AnneDepartment of Pathology, Rikshospitalet-Radiumhospitalet-HF, Oslo, Norway (author)
  • Axelsson, Susanne,1976-Department of Pathology, Örebro University Hospital (USÖ), Örebro, Sweden(Swepub:oru)suan (author)
  • Forestier, ErikUmeå universitet,Pediatrik,Department of Pathology and Cytology, University Hospital Umeå, Sweden(Swepub:umu)erfo0007 (author)
  • Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Laboratory of Clinical Chemistry Sahlgrenska/SU, Göteborg, Sweden(Swepub:gu)xjacst (author)
  • Ahlberg, Asa JeppssonDepartment of Pathology and Cytology, Karolinska University Hospital, Huddinge, Karolinska Institute, Stockholm, Sweden (author)
  • Kauric, GoranDepartment of Immunology, Transfusion Medicine University Hospital of North Norway, Tromsö, Norway (author)
  • Mäntymaa, Penttientre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland (author)
  • Osnes, LivDepartment of Immunology and Transfusion Medicine, Ullevål University Hospital, Norway (author)
  • Penttilä, Tarja-LeenaDepartment of Immunology and Transfusion Medicine, TYKSLAB, Turku University Hospital, Turku, Finland (author)
  • Marquart, HanneDepartment of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark (author)
  • Savolainen, Eeva-RiittaDepartment of Hematology, Hematology Laboratory, Oulu University Hospital, Finland (author)
  • Siitonen, SannaDepartment of Clinical Chemistry and Hematology, HUSLAB, Helsinki University Hospital, Helsinki, Finland (author)
  • Torikka, KerstinICH-laboratory Blood Center, Lund University Hospital, Lund, Sweden (author)
  • Mazur, JoannaDepartment of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland (author)
  • Porwit, AnnaKarolinska Institutet (author)
  • Department of Pathology and Cytology, Karolinska University Hospital, Solna, SwedenDepartment of Clinical Chemistry and Hematology, Kuopio University Hospital, Kuopio, Finland (creator_code:org_t)

Related titles

  • In:Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology: Lippincott Williams & Wilkins31:6, s. 406-151536-36781077-4114

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