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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006243naa a2200733 4500
001oai:lup.lub.lu.se:5abe1ce8-efbe-4d45-bf2d-fb72f16334e4
003SwePub
008240115s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/5abe1ce8-efbe-4d45-bf2d-fb72f16334e42 URI
0247 a https://doi.org/10.1002/art.426452 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Nguyen, Yannu Cochin Hospital4 aut
2451 0a Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the SLICC Inception Cohort
264 1c 2023
300 a 12 s.
520 a Objective: The goals of this study were to assess the associations of severe nonadherence to hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates over five years of follow-up. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort is an international multicenter initiative (33 centers throughout 11 countries). The serum of patients prescribed HCQ for at least three months at enrollment were analyzed. Severe nonadherence was defined by a serum HCQ level <106 ng/mL or <53 ng/mL for HCQ doses of 400 or 200 mg/day, respectively. Associations with the risk of a flare (defined as a Systemic Lupus Erythematosus Disease Activity Index 2000 increase ≥4 points, initiation of prednisone or immunosuppressive drugs, or new renal involvement) were studied with logistic regression, and associations with damage (first SLICC/American College of Rheumatology Damage Index [SDI] increase ≥1 point) and mortality with separate Cox proportional hazard models. Results: Of the 1,849 cohort participants, 660 patients (88% women) were included. Median (interquartile range) serum HCQ was 388 ng/mL (244–566); 48 patients (7.3%) had severe HCQ nonadherence. No covariates were clearly associated with severe nonadherence, which was, however, independently associated with both flare (odds ratio 3.38; 95% confidence interval [CI] 1.80–6.42) and an increase in the SDI within each of the first three years (hazard ratio [HR] 1.92 at three years; 95% CI 1.05–3.50). Eleven patients died within five years, including 3 with severe nonadherence (crude HR 5.41; 95% CI 1.43–20.39). Conclusion: Severe nonadherence was independently associated with the risks of an SLE flare in the following year, early damage, and five-year mortality. (Figure presented.).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Blanchet, Benoîtu Université Paris Cité4 aut
7001 a Urowitz, Murray B.u University of Toronto4 aut
7001 a Hanly, John G.u Dalhousie University4 aut
7001 a Gordon, Carolineu University of Birmingham4 aut
7001 a Bae, Sang Cheolu Hanyang University Hospital for Rheumatic Disease4 aut
7001 a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut
7001 a Sanchez-Guerrero, Jorgeu Mount Sinai Hospital of University of Toronto4 aut
7001 a Clarke, Ann E.u Cumming School of Medicine4 aut
7001 a Bernatsky, Sashau McGill University Health Center4 aut
7001 a Wallace, Daniel J.u University of California, Los Angeles4 aut
7001 a Isenberg, David A.u University College London4 aut
7001 a Rahman, Anisuru University College London4 aut
7001 a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut
7001 a Fortin, Paul R.u Centre hospitalier universitaire de Québec4 aut
7001 a Gladman, Dafna D.u University of Toronto4 aut
7001 a Bruce, Ian N.u Manchester Academic Health Science Centre4 aut
7001 a Petri, Michelleu Johns Hopkins University School of Medicine4 aut
7001 a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut
7001 a Dooley, Mary Anneu University of North Carolina4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut
7001 a Manzi, Susanu Allegheny Health Network4 aut
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo
7001 a Alarcón, Graciela S.u University of Alabama4 aut
7001 a Van Vollenhoven, Ronald F.u University of Amsterdam4 aut
7001 a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut
7001 a Le Guern, Véroniqueu Cochin Hospital4 aut
7001 a Mackay, Megganu Feinstein Institute for Medical Research4 aut
7001 a Ruiz-Irastorza, Guillermou University of the Basque Country4 aut
7001 a Lim, S. Samu Emory University4 aut
7001 a Inanc, Muratu Istanbul University4 aut
7001 a Kalunian, Kenneth C.u University of California, San Diego4 aut
7001 a Jacobsen, Sørenu Copenhagen University Hospital4 aut
7001 a Peschken, Christine A.u University of Manitoba4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina4 aut
7001 a Askanase, Ancau Indian Institute of Technology4 aut
7001 a Buyon, Jillu NYU Grossman School of Medicine4 aut
7001 a Costedoat-Chalumeau, Nathalieu Cochin Hospital4 aut
7102 a Cochin Hospitalb Université Paris Cité4 org
7730 t Arthritis and Rheumatologyg 75:12, s. 2195-2206q 75:12<2195-2206x 2326-5191
8564 u http://dx.doi.org/10.1002/art.42645x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/5abe1ce8-efbe-4d45-bf2d-fb72f16334e4
8564 8u https://doi.org/10.1002/art.42645

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