Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with Lofgren's syndrome

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Ostadkarampour, M.Karolinska Institutet (författare)

Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with Lofgren's syndrome

Artikel/kapitelEngelska2014

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2014-10-01
Oxford University Press (OUP),2014

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LIBRIS-ID:oai:gup.ub.gu.se/205348
https://gup.ub.gu.se/publication/205348URI
https://doi.org/10.1111/cei.12403DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:129870641URI

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Språk:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Sarcoidosis is a granulomatous disorder of unknown aetiology. The presence of Mycobacterium tuberculosis catalase-peroxidase (mKatG) in sarcoidosis tissue has been reported. T helper type 1 (Th1) responses against mKatG have previously been observed. However, little is known about interleukin (IL)-17 and Th17 responses in sarcoidosis. Here, we investigated the levels of IL-17 and frequencies of IL-17-producing cells responding to mKatG in sarcoidosis patients with different prognosis. Peripheral blood and bronchoalveolar lavage (BAL) cells were obtained from sarcoidosis patients with or without Lofgren's syndrome (often associated with spontaneous recovery), and also stratified according to human leucocyte antigen (HLA) type. Cells producing IL-17 and interferon (IFN)-gamma after stimulation with mKatG were enumerated by enzyme-linked immunospot (ELISPOT). The level of IL-17 in the BAL fluid of sarcoidosis patients and healthy controls was measured by quantitative immuno-polymerase chain reaction (qIPCR). We also performed flow cytometry and immunohistochemistry for further characterization of IL-17 expression. Patients with Lofgren's syndrome had a higher frequency of IL-17-producing cells responding to mKatG in BAL fluid compared to patients without Lofgren's syndrome (P < 0.05). The HLA-DR3(+) sarcoidosis patients with Lfgren's syndrome (known to have a particularly good prognosis) also had a clearly higher level of IL-17 in BAL fluid compared to healthy controls and sarcoidosis patients without Lofgren's syndrome (P < 0.01) and (P < 0.05), respectively. No such difference between patient groups was observed with regard to IFN-gamma and not with regard to either cytokine in peripheral blood. These findings suggest that IL-17-producing cells may be a useful biomarker for the prognosis of sarcoidosis and play a role in the spontaneous recovery typical of patients with Lfgren's syndrome.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
cytokines
IL-17
inflammation
sarcoidosis
T cells
MYCOBACTERIAL CATALASE-PEROXIDASE
PATHOGENIC T(H)17 CELLS
SYSTEMIC
SARCOIDOSIS
IMMUNE-RESPONSE
TH17 CELLS
T-CELLS
INFLAMMATION
LUNG
TUBERCULOSIS
RECRUITMENT
Immunology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Eklund, A.Karolinska Institutet (författare)
Moller, D. (författare)
Glader, Pernilla,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xglape (författare)
Hoglund, C. O.Karolinska Institutet (författare)
Linden, A.Karolinska Institutet (författare)
Grunewald, J.Karolinska Institutet (författare)
Wahlstrom, J.Karolinska Institutet (författare)
Karolinska InstitutetInstitutionen för medicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical and Experimental Immunology: Oxford University Press (OUP)178:2, s. 342-3520009-91041365-2249

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Clinical and Experimental Immunology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Ostadkarampour, ...; Eklund, A.; Moller, D.; Glader, Pernilla ...; Hoglund, C. O.; Linden, A.; visa fler...; Grunewald, J.; Wahlstrom, J.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

Artiklar i publikationen: Clinical and Exp ...

Av lärosätet: Göteborgs universitet; Karolinska Institutet

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