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Multicenter reprodu...
Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic zero referencing
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- Deh, Kofi (författare)
- Cornell University
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- Kawaji, Keigo (författare)
- University of Chicago Medical Center,Illinois Institute of Technology
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- Bulk, Marjolein (författare)
- Leiden University Medical Centre
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- Van Der Weerd, Louise (författare)
- Leiden University Medical Centre
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- Lind, Emelie (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Spincemaille, Pascal (författare)
- Cornell University
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- McCabe Gillen, Kelly (författare)
- Cornell University
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- Van Auderkerke, Johan (författare)
- University of Antwerp
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- Wang, Yi (författare)
- Cornell University
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- Nguyen, Thanh D. (författare)
- Cornell University
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(creator_code:org_t)
- 2018-10-04
- 2019
- Engelska 8 s.
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 81:2, s. 1229-1236
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 T, 7 T, and 9.4 T) from different vendors (Siemens, GE, Philips, and Bruker) for standardization of multicenter studies. Methods: Seven phantoms distributed from the core site, each containing 5 compartments with gadolinium solutions with fixed concentrations between 0.625 mM and 10 mM. Multi-echo gradient echo scans were performed at 1.5 T, 3 T, 7 T, and 9.4 T on 12 clinical and 3 preclinical scanners. DICOM images from the scans were processed into quantitative susceptibility maps using the Laplacian boundary value (LBV) and MEDI+0 automatic uniform reference algorithm. Region of interest (ROI) analyses were performed by a physicist to determine agreement between results from all sites. Measurement reproducibility was assessed using regression, Bland-Altman plots, and the intra-class correlation coefficient (ICC). Results: Quantitative susceptibility mapping (QSM) from all scanners had similar, artifact-free visual appearance. Regression analysis showed a linear relationship between gadolinium concentrations and average QSM measurements for all phantoms (y = 350x – 0.0346, r2>0.99). The SD of measurements increased almost linearly from 32 ppb to 230 ppb as the measured susceptibility increased from 0.26 ppm to 3.56 ppm. A Bland-Altman plot showed the bias, upper, and lower limits of agreement for all comparisons were −10, −210, and 200 ppb, respectively. The ICC was 0.991 with a 95% CI (0.973, 0.99). Conclusions: QSM shows excellent multicenter reproducibility for a large range of susceptibility values encountered in cranial and extra-cranial applications on a diverse set of scanner platforms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- multicenter reproducibility
- quantitative susceptibility mapping
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Deh, Kofi
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Kawaji, Keigo
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Bulk, Marjolein
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Van Der Weerd, L ...
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Lind, Emelie
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Spincemaille, Pa ...
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visa fler...
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McCabe Gillen, K ...
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Van Auderkerke, ...
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Wang, Yi
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Nguyen, Thanh D.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Annan fysik
- Artiklar i publikationen
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Magnetic Resonan ...
- Av lärosätet
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Lunds universitet