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Two years of adjuva...
Two years of adjuvant tamoxifen in premenopausal patients with breast cancer : a randomised, controlled trial with long-term follow-up
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- Rydén, Lisa (author)
- Department of Surgery, Helsingborgs Lasarett, Helsingborg, Sweden and Department of Laboratory Medicine, div of Pathology, University Hospital, Malmö
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- Jönsson, Per-Ebbe (author)
- Department of Surgery, Helsingborgs Lasarett, Helsingborg, Sweden
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- Chebil, Gunilla (author)
- Department of Pathology, Helsingborgs Lasarett, Helsingborg
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- Dufmats, Monika, 1943- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Fernö, Mårten (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, University Hospital, Lund
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Laboratory Medicine, div of Pathology, University Hospital, Malmö
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- Källström, Ann-Christine, 1953- (author)
- Östergötlands Läns Landsting,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala
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- Landberg, Göran (author)
- Department of Laboratory Medicine, div of Pathology, University Hospital, Malmö
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- Stål, Olle, 1952- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Thorstenson, Sten, 1950- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Nordenskjöld, Bo, 1940- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 41:2, s. 256-264
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- Adjuvant tamoxifen treatment increases recurrence-free survival (RFS) and overall survival (OS) in early breast cancer, although in premenopausal patients the number of studies comparing tamoxifen vs no treatment are limited. We report herein the effect on RFS of adjuvant tamoxifen treatment in a multicentre trial of premenopausal patients with stage II breast cancer patients randomised between 1986 and 1991 to 2 years of tamoxifen treatment (n = 276) or no treatment (n = 288). The receptor status of the tumour was known for 541 (96%) of the patients included. Tamoxifen treatment significantly increased RFS in patients with hormone receptor-positive (oestrogen receptor-positive (ER+) and/or progesterone receptor-positive (PR+)) tumours (Relative Risk (RR) 0.65; 95% Confidence Interval (CI): 0.48–0.89, P = 0.006), and the beneficial effect of tamoxifen was extended to patients with indicators of poor prognosis, such as young age and nodal-positivity. PR status was a significant predictor of response to tamoxifen in multivariate models with testing of interactions of hormone receptor status and adjuvant therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rydén, Lisa
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Jönsson, Per-Ebb ...
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Chebil, Gunilla
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Dufmats, Monika, ...
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Fernö, Mårten
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Jirström, Karin
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Källström, Ann-C ...
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Landberg, Göran
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Stål, Olle, 1952 ...
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Thorstenson, Ste ...
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Nordenskjöld, Bo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Lund University