Vitamin D C3 epimer in a mid-Swedish region: Analytical measurement and epidemiology

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Vitamin D C3 epimer in a mid-Swedish region : Analytical measurement and epidemiology

Karefylakis, Christos, 1982- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology

Pettersson-Pablo, Paul, 1986- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden

Särnblad, Stefan, 1963- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Pediatrics

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Rask, Eva, 1958- (författare): Department of Endocrinology, School of Medical Sciences, Örebro University, Örebro, Sweden

Bitar, Manar (författare): Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden

Magnusson, Anders (författare): Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden

Eriksson, Clas-Göran (författare): Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden

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Amsterdam, Netherlands : Elsevier, 2018
2018
Engelska.
Ingår i: Clinica Chimica Acta. - Amsterdam, Netherlands : Elsevier. - 0009-8981 .- 1873-3492. ; 478, s. 182-187

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

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Background: The discovery of an epimeric form of 25(OH)D3 may complicate the interpretation of vitamin Dstatus. The aim of this study was to examine the prevalence and determinants of 25-hydroxy-3-epi-vitamin D3 (3- epi-25(OH)D3) in a mid-Swedish region and to investigate how the measurement of 3-epi-25(OH)D3 would affect the assessment of vitamin D status using current thresholds.Methods: We conducted a cross-sectional study of 8286 in- and outpatients in primary as well as secondary care settings. Plasma 25(OH)D, 25(OH)D2, 25(OH)D3 and 3-epi-25(OH)D3 were measured using High Pressure Liquid Chromatography – Tandem Mass Spectrometry (HPLC – MS/MS). The relative 3-epi-25(OH)D3 contribution was calculated as a percentage of the total 25(OH)D3. Blood samples were collected between March 2014 and July 2015 providing a seasonal aspect to the results.Results: 3-epi-25(OH)D3was detected in 635 cases (7.7% of all subjects), and the mean concentration was8.4 ± 3.5 nmol/L. 3-epi-25(OH)D3correlated significantly with 25(OH)D3(r =0.38, p < 0.001).A multivariateanalysis among the detected showed that male gender and winter season were independently associatedwith higher 3-epi-25(OH)D3/25(OH)D3percentage ratio (R2=0.044). Infants and children had a significantlyhigher detection rate compared to the reference age category (18–45 years) as well as those who were testedduring the summer season.Conclusions: We report findings from the first epidemiologic study of 3-epi-25(OH)D3 conducted in Sweden, based on a large population sample. 3-epi-25(OH)D3 was detected in 7.7% of the study population and the mean concentration was 8.4 nmol/L. The quantification of 3-epi-25(OH)D3 would not significantly influence the clinical interpretation of vitamin D levels. Additional studies are needed to understand the metabolic pathway and the possible physiological functions of this metabolite.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Nyckelord

3-epi 25(OH)D(3)
25(OH)D(3)
High Pressure Liquid Chromatography – Tandem Mass Spectrometry (HPLC – MS/MS)
Vitamin D

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Av författaren/redakt...: Karefylakis, Chr ...; Pettersson-Pablo ...; Särnblad, Stefan ...; Rask, Eva, 1958-; Bitar, Manar; Magnusson, Ander ...; visa fler...; Eriksson, Clas-G ...; visa färre...

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