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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003821naa a2200517 4500
001oai:DiVA.org:uu-164550
003SwePub
008111221s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123613586
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1645502 URI
0247 a https://doi.org/10.1111/j.1476-5381.2011.01499.x2 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1236135862 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kehr, J.u Karolinska Institutet4 aut
2451 0a Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
264 c 2011-11-21
264 1b Wiley,c 2011
338 a print2 rdacarrier
520 a BACKGROUND AND PURPOSE The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1-one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine (DA) and 5-HT in the nucleus accumbens of awake rats and compare these effects with those induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine. EXPERIMENTAL APPROACH Microdialysis sampling was performed while simultaneously recording locomotor activity in rats and the monoamines were determined by HPLC with electrochemical detection. KEY RESULTS Mephedrone (3 mg·kg−1 s.c.) and (+)-amphetamine (1 mg·kg−1 s.c.) caused rapid increases in extracellular DA levels of 496% and 412%, respectively, whereas MDMA (3 mg·kg−1 s.c.) showed only a moderate effect (235%). The corresponding 5-HT levels increased to 941% (mephedrone) and 911% (MDMA), but only to 165% following amphetamine. The calculated t1/2 values for elimination rate of mephedrone, MDMA and amphetamine-induced increases in extracellular DA levels were 25, 303 and 51 min, the corresponding t1/2 values for 5-HT were 26, 48 and 84 min, respectively. Locomotor activity was increased most by amphetamine, whereas both mephedrone and MDMA showed about three times lower and shorter-lasting effects. CONCLUSIONS AND IMPLICATIONS The neurochemical and functional properties of mephedrone resemble those of MDMA, but it also shows an amphetamine-like effect in that it evokes a rapid release and elimination of DA in the brain reward system, a feature that may contribute to its potent re-inforcing properties.
653 a 4-methylmethcathinone
653 a cathinones
653 a phenethylamines
653 a 3
653 a 4-methylenedioxymethamphetamine
653 a microdialysis
653 a dopamine
653 a 5-HT
653 a serotonin
653 a legal highs
653 a psychostimulants
7001 a Ichinose, F.4 aut
7001 a Yoshitake, S.u Karolinska Institutet4 aut
7001 a Goiny, M.u Karolinska Institutet4 aut
7001 a Sievertsson, T.4 aut
7001 a Nyberg, Fredu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)frednybe
7001 a Yoshitake, T.u Karolinska Institutet4 aut
7102 a Karolinska Institutetb Institutionen för farmaceutisk biovetenskap4 org
7730 t British Journal of Pharmacologyd : Wileyg 164:8, s. 1949-1958q 164:8<1949-1958x 0007-1188x 1476-5381
8564 u https://europepmc.org/articles/pmc3246659?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164550
8564 8u https://doi.org/10.1111/j.1476-5381.2011.01499.x
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123613586

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