The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila

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Fältnamn	Indikatorer	Metadata
000		04749naa a2200529 4500
001		oai:research.chalmers.se:ba385847-b42a-42f9-ad9c-6b7911153699
003		SwePub
008		191208s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:gup.ub.gu.se/287727
024	7	a https://doi.org/10.1016/j.ijantimicag.2019.09.0172 DOI
024	7	a https://research.chalmers.se/publication/5141862 URI
024	7	a https://gup.ub.gu.se/publication/2877272 URI
040		a (SwePub)cthd (SwePub)gu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ebmeyer, Stefan,d 1990u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xebmst
245	1 0	a The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila
264	1	b Elsevier BV,c 2019
338		a electronic2 rdacarrier
520		a Objective: It is important to understand the origins of antibiotic resistance genes so that risks associated with the emergence of novel resistance genes can be assessed and managed. The chromosomal ampC gene (CAV-1) of Aeromonas caviae (A. caviae) has been reported as the origin of mobile FOX cephalosporinases. The recent identification of A. caviae as the origin of MOX-2 cephalosporinases and the comparably great sequence divergence between FOX and MOX genes makes it unlikely that both genes arose from the same species. Therefore, this study investigated the origin of FOX cephalosporinases using large-scale genomics. Methods: Publicly available genomes and plasmids were searched for FOX-like genes. Synteny and nucleotide identities of the identified FOX-like genes and their genetic environments were compared and a phylogenetic tree was generated. Results: FOX-like genes were identified in > 230 Aeromonas genomes and in 46 Enterobacteriaceae isolates. Analysis of the genomic context of CAV-1 revealed a truncated insertion sequence directly upstream of the ampC gene. The chromosomal ampCs of A. caviae (n = 31) were 75–78% identical to CAV-1. In contrast, CAV-1, mobile FOX genes and their context were 95–98% similar to the chromosomal ampC-locus of Aeromonas allosaccharophila (A. allosaccharophila) (n = 6). The A. allosaccharophila ampCs formed a monophyletic branch with mobile FOX genes, whereas the A. caviae ampCs clustered with mobile MOX genes. Conclusions: These findings show that FOX cephalosporinases originate not in A. caviae, as previously reported, but in A. allosaccharophila, which is a fish pathogen. This finding agrees with the hypothesis that antibiotic use in aquaculture could have contributed to the emergence of FOX genes in human pathogens.
650	7	a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650	7	a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
650	7	a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653		a AmpC
653		a FOX
653		a Aeromonas
653		a Antibiotic resistance
653		a Aeromonas
653		a AmpC
653		a Antibiotic resistance
653		a FOX
700	1	a Kristiansson, Erik,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences4 aut0 (Swepub:gu)xkrier
700	1	a Larsson, D. G. Joakim,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xlarjo
710	2	a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org
773	0	t International Journal of Antimicrobial Agentsd : Elsevier BVg 54:6, s. 798-802q 54:6<798-802x 1872-7913x 0924-8579
856	4	u https://research.chalmers.se/publication/514186/file/514186_Fulltext.pdfx primaryx freey FULLTEXT
856	4	u https://doi.org/10.1016/j.ijantimicag.2019.09.017
856	4 8	u https://doi.org/10.1016/j.ijantimicag.2019.09.017
856	4 8	u https://research.chalmers.se/publication/514186
856	4 8	u https://gup.ub.gu.se/publication/287727

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