Testosterone Levels in People Taking Regular Low-Dose Sustained-Release Morphine for Persisting Breathlessness : An Exploratory Study

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Fältnamn	Indikatorer	Metadata
000		03229naa a2200397 4500
001		oai:lup.lub.lu.se:8fd256a0-1d9f-4432-b36b-8b5014b1cbd5
003		SwePub
008		240112s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/8fd256a0-1d9f-4432-b36b-8b5014b1cbd52 URI
024	7	a https://doi.org/10.1089/jpm.2022.03812 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ferreira, Diana H.u University of Wollongong4 aut
245	1 0	a Testosterone Levels in People Taking Regular Low-Dose Sustained-Release Morphine for Persisting Breathlessness : An Exploratory Study
264	1	b Mary Ann Liebert Inc,c 2023
300		a 4 s.
520		a Background: The intermediate- and long-term effects of regular low-dose sustained-release (SR) morphine on the testosterone levels of people with persistent breathlessness are unknown. Methods: Exploratory analysis of a randomized controlled trial of the effects of regular SR morphine (0/8/16/24 mg every 24 hours) for persistent breathlessness associated with chronic obstructive pulmonary disease. Total testosterone was measured at baseline and at cessation (greater than or equal to three months on stable medication). Results: Among 20 participants (9 males; median treatment duration between measurements 169 days [IQR 162-175]), only 3 had substantial declines in testosterone levels during the study (morphine 8, 16, 24 mg groups). All three had worsening illness at the time of the second assessment. There was no apparent relationship between change in testosterone, morphine dose, and change in breathlessness. Conclusions: Substantial declines in testosterone were uncommon and were not apparently related to changes in morphine dose or breathlessness, but they were possibly related with worsening illness.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653		a persistent breathlessness
653		a placebo
653		a randomized controlled trial
653		a safety
653		a sustained-release morphine
653		a testosterone
700	1	a Ekstrom, Magnusu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mue
700	1	a Fazekas, Belindau University of Technology Sydney4 aut
700	1	a Currow, David C.u University of Wollongong4 aut
710	2	a University of Wollongongb Lungmedicin, allergologi och palliativ medicin4 org
773	0	t Journal of Palliative Medicined : Mary Ann Liebert Incg 26:3, s. 402-405q 26:3<402-405x 1096-6218x 1557-7740
856	4	u http://dx.doi.org/10.1089/jpm.2022.0381y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/8fd256a0-1d9f-4432-b36b-8b5014b1cbd5
856	4 8	u https://doi.org/10.1089/jpm.2022.0381

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Av författaren/redakt...: Ferreira, Diana ...; Ekstrom, Magnus; Fazekas, Belinda; Currow, David C.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Lunds universitet

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