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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06260naa a2201093 4500 | |
| 001 | oai:DiVA.org:uu-520258 | |
| 003 | SwePub | |
| 008 | 240111s2024 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:238047387 | |
| 009 | oai:prod.swepub.kib.ki.se:154767020 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5202582 URI |
| 024 | 7 | a https://doi.org/10.1161/CIRCULATIONAHA.123.0655302 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2380473872 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1547670202 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Laguzzi, F.4 aut |
| 245 | 1 0 | a Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease :b Pooled De Novo Results From 15 Observational Studies |
| 264 | 1 | b Wolters Kluwer,c 2024 |
| 338 | a electronic2 rdacarrier | |
| 520 | a BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction.RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions.CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 653 | a biomarkers | |
| 653 | a cardiovascular diseases | |
| 653 | a fatty acids | |
| 653 | a unsaturated | |
| 653 | a medical history taking | |
| 653 | a precision medicine | |
| 700 | 1 | a Åkesson, A.u Karolinska Institutet4 aut |
| 700 | 1 | a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)matma701 |
| 700 | 1 | a Qian, F.4 aut |
| 700 | 1 | a Gigante, B.u Karolinska Institutet4 aut |
| 700 | 1 | a Bartz, T. M.4 aut |
| 700 | 1 | a Bassett, J. K.4 aut |
| 700 | 1 | a Birukov, A.4 aut |
| 700 | 1 | a Campos, H.4 aut |
| 700 | 1 | a Hirakawa, Y.4 aut |
| 700 | 1 | a Imamura, F.4 aut |
| 700 | 1 | a Jäger, S.4 aut |
| 700 | 1 | a Lankinen, M.4 aut |
| 700 | 1 | a Murphy, R. A.4 aut |
| 700 | 1 | a Senn, M.4 aut |
| 700 | 1 | a Tanaka, T.4 aut |
| 700 | 1 | a Tintle, N.4 aut |
| 700 | 1 | a Virtanen, J. K.4 aut |
| 700 | 1 | a Yamagishi, K.4 aut |
| 700 | 1 | a Allison, M.4 aut |
| 700 | 1 | a Brouwer, I. A.4 aut |
| 700 | 1 | a De Faire, U.4 aut |
| 700 | 1 | a Eiriksdottir, G.4 aut |
| 700 | 1 | a Ferrucci, L.4 aut |
| 700 | 1 | a Forouhi, N. G.4 aut |
| 700 | 1 | a Geleijnse, J. M.4 aut |
| 700 | 1 | a Hodge, A. M.4 aut |
| 700 | 1 | a Kimura, H.4 aut |
| 700 | 1 | a Laakso, M.4 aut |
| 700 | 1 | a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser |
| 700 | 1 | a van Westing, A. C.4 aut |
| 700 | 1 | a Bandinelli, S.4 aut |
| 700 | 1 | a Baylin, A.4 aut |
| 700 | 1 | a Giles, G. G.4 aut |
| 700 | 1 | a Gudnason, V.4 aut |
| 700 | 1 | a Iso, H.4 aut |
| 700 | 1 | a Lemaitre, R. N.4 aut |
| 700 | 1 | a Ninomiya, T.4 aut |
| 700 | 1 | a Post, W. S.4 aut |
| 700 | 1 | a Psaty, B. M.4 aut |
| 700 | 1 | a Salonen, J. T.4 aut |
| 700 | 1 | a Schulze, M. B.4 aut |
| 700 | 1 | a Tsai, M. Y.4 aut |
| 700 | 1 | a Uusitupa, M.4 aut |
| 700 | 1 | a Wareham, N. J.4 aut |
| 700 | 1 | a Oh, S.-W.4 aut |
| 700 | 1 | a Wood, A. C.4 aut |
| 700 | 1 | a Harris, W. S.4 aut |
| 700 | 1 | a Siscovick, D.4 aut |
| 700 | 1 | a Mozaffarian, D.4 aut |
| 700 | 1 | a Leander, K.u Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Klinisk nutrition och metabolism4 org |
| 773 | 0 | t Circulationd : Wolters Kluwerg 149:4, s. 305-316q 149:4<305-316x 0009-7322x 1524-4539 |
| 856 | 4 | u https://doi.org/10.1161/CIRCULATIONAHA.123.065530y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1826619/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520258 |
| 856 | 4 8 | u https://doi.org/10.1161/CIRCULATIONAHA.123.065530 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:238047387 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:154767020 |
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- Tintle, N.
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- Yamagishi, K.
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- Eiriksdottir, G.
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- Post, W. S.
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- Salonen, J. T.
- Schulze, M. B.
- Tsai, M. Y.
- Uusitupa, M.
- Wareham, N. J.
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