Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

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Fältnamn	Indikatorer	Metadata
000		08992naa a2201813 4500
001		oai:gup.ub.gu.se/144667
003		SwePub
008		240528s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:c012bec6-2fe3-4802-80be-8e4858e52cec
009		oai:prod.swepub.kib.ki.se:122999383
009		oai:DiVA.org:uu-157022
024	7	a https://gup.ub.gu.se/publication/1446672 URI
024	7	a https://doi.org/10.1038/ng.8662 DOI
024	7	a https://lup.lub.lu.se/record/20718612 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1229993832 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1570222 URI
040		a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)uu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kilpeläinen, Tuomas O4 aut
245	1 0	a Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
264		c 2011-06-26
264	1	b Springer Science and Business Media LLC,c 2011
520		a Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a MEDICINE
700	1	a Zillikens, M Carola4 aut
700	1	a Stančákova, Alena4 aut
700	1	a Finucane, Francis M4 aut
700	1	a Ried, Janina S4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Zhang, Weihua4 aut
700	1	a Beckmann, Jacques S4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xvanli
700	1	a Styrkarsdottir, Unnur4 aut
700	1	a Zhou, Yanhua4 aut
700	1	a Smith, Albert Vernon4 aut
700	1	a Zhao, Jing-Hua4 aut
700	1	a Amin, Najaf4 aut
700	1	a Vedantam, Sailaja4 aut
700	1	a Shin, So-Youn4 aut
700	1	a Haritunians, Talin4 aut
700	1	a Fu, Mao4 aut
700	1	a Feitosa, Mary F4 aut
700	1	a Kumari, Meena4 aut
700	1	a Halldorsson, Bjarni V4 aut
700	1	a Tikkanen, Emmi4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Song, Ciu Karolinska Institutet4 aut
700	1	a Arnold, Alice M4 aut
700	1	a Aulchenko, Yurii S4 aut
700	1	a Oostra, Ben A4 aut
700	1	a Campbell, Harry4 aut
700	1	a Cupples, L Adrienne4 aut
700	1	a Davis, Kathryn E4 aut
700	1	a Döring, Angela4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Estrada, Karol4 aut
700	1	a Fernández-Real, José Manuel4 aut
700	1	a Garcia, Melissa4 aut
700	1	a Gieger, Christian4 aut
700	1	a Glazer, Nicole L4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Hofman, Albert4 aut
700	1	a Humphries, Steve E4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jacobs, Leonie C4 aut
700	1	a Jula, Antti4 aut
700	1	a Karasik, David4 aut
700	1	a Karlsson, Magnus K.u Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)orto-mka
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kim, Lauren J4 aut
700	1	a Kivimäki, Mika4 aut
700	1	a Klopp, Norman4 aut
700	1	a Kühnel, Brigitte4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Ljunggren, Östenu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)osteljun
700	1	a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat
700	1	a Luben, Robert N4 aut
700	1	a McKnight, Barbara4 aut
700	1	a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xmelda
700	1	a Mitchell, Braxton D4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Moreno, José Maria4 aut
700	1	a Männistö, Satu4 aut
700	1	a O'Connell, Jeffery R4 aut
700	1	a Pascoe, Laura4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Peral, Belén4 aut
700	1	a Perola, Markus4 aut
700	1	a Psaty, Bruce M4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Savage, David B4 aut
700	1	a Semple, Robert K4 aut
700	1	a Skaric-Juric, Tatjana4 aut
700	1	a Sigurdsson, Gunnar4 aut
700	1	a Song, Kijoung S4 aut
700	1	a Spector, Timothy D4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva
700	1	a Talmud, Philippa J4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Vidal-Puig, Antonio4 aut
700	1	a Wild, Sarah H4 aut
700	1	a Wright, Alan F4 aut
700	1	a Clegg, Deborah J4 aut
700	1	a Schadt, Eric4 aut
700	1	a Wilson, James F4 aut
700	1	a Rudan, Igor4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Borecki, Ingrid B4 aut
700	1	a Shuldiner, Alan R4 aut
700	1	a Ingelsson, Eriku Uppsala universitet,Karolinska Institutet,Geriatrik4 aut0 (Swepub:uu)ering425
700	1	a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo
700	1	a Kaplan, Robert C4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Harris, Tamara B4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Kiel, Douglas P4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Walker, Mark4 aut
700	1	a Barroso, Inês4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gérard4 aut
700	1	a Chambers, John C4 aut
700	1	a Kooner, Jaspal S4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xohlcl
700	1	a O'Rahilly, Stephen4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Speliotes, Elizabeth K4 aut
700	1	a Fox, Caroline S4 aut
700	1	a Laakso, Markku4 aut
700	1	a Loos, Ruth J F4 aut
710	2	a Göteborgs universitetb Centre for Bone and Arthritis Research4 org
773	0	t Nature geneticsd : Springer Science and Business Media LLCg 43:8, s. 753-60q 43:8<753-60x 1546-1718x 1061-4036
856	4	u https://europepmc.org/articles/pmc3262230?pdf=render
856	4	u http://dx.doi.org/10.1038/ng.866y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/144667
856	4 8	u https://doi.org/10.1038/ng.866
856	4 8	u https://lup.lub.lu.se/record/2071861
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122999383
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157022

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