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Advances in genome-...
Advances in genome-scale metabolic models of industrially important fungi
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- Han, Yichao (författare)
- Pacific Northwest National Laboratory
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- Tafur Rangel, Albert Enrique, 1992 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Novo Nordisk Fonden,Novo Nordisk Foundation
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- Pomraning, Kyle R. (författare)
- Pacific Northwest National Laboratory
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- Kerkhoven, Eduard, 1985 (författare)
- Science for Life Laboratory (SciLifeLab),Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology
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- Kim, Joonhoon (författare)
- Pacific Northwest National Laboratory,United States Department of Energy
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Current Opinion in Biotechnology. - 0958-1669 .- 1879-0429. ; 84
- Relaterad länk:
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Many fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved predictions of cell states and proteome allocation. Here, we provide an overview of these newly developed GEMs and computational methods that facilitate construction of enzyme-constrained GEMs and utilize flux predictions from GEMs. Furthermore, we highlight the pivotal roles of these GEMs in iterative design–build–test–learn cycles, ultimately advancing the field of fungal biomanufacturing.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Programvaruteknik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Software Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- Genome-scale metabolic models
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