AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks

AVRA : Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks

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Related links:: https://doi.org/10.1...; show more...; http://adni.loni.usc...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

Quantifying the degree of atrophy is done clinically by neuroradiologists following established visual rating scales. For these assessments to be reliable the rater requires substantial training and experience, and even then the rating agreement between two radiologists is not perfect. We have developed a model we call AVRA (Automatic Visual Ratings of Atrophy) based on machine learning methods and trained on 2350 visual ratings made by an experienced neuroradiologist. It provides fast and automatic ratings for Scheltens' scale of medial temporal atrophy (MTA), the frontal subscale of Pasquier's Global Cortical Atrophy (GCA-F) scale, and Koedam's scale of Posterior Atrophy (PA). We demonstrate substantial inter-rater agreement between AVRA's and a neuroradiologist ratings with Cohen's weighted kappa values of kappa(w) = 0.74/0.72 (MTA left/right), kappa(w) = 0.62 (GCA-F) and kappa(w) = 0.74 (PA). We conclude that automatic visual ratings of atrophy can potentially have great scientific value, and aim to present AVRA as a freely available toolbox.

By the author/editor: Mårtensson, Gust ...; Ferreira, Daniel; Cavallin, Lena; Muehlboeck, J-Se ...; Wahlund, Lars-Ol ...; Wang, Chunliang, ...; show more...; Westman, Eric; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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