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  • Sivars, LarsKarolinska Institutet (author)

Human papillomavirus DNA detection in fine-needle aspirates as indicator of human papillomavirus-positive oropharyngeal squamous cell carcinoma : A prospective study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-11-29
  • Wiley,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-320276
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320276URI
  • https://doi.org/10.1002/hed.24641DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135492038URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background. Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) has a better outcome than most head neck squamous cell carcinomas (HNSCCs) and an HPV-positive lymph node metastasis likely has an HPV-positive oropharyngeal SCC origin. Determining HPV-status in cervical lymph nodes by fine-needle aspiration cytology (FNAC) may be useful for diagnosis. Methods. FNACs from 66 patients with neck masses were prospectively examined for HPV DNA and HPV16 mRNA by a polymerase chain reaction (PCR)-based assay, and the data correlated to diagnosis and HPV-status obtained from histopathological specimens. Results. Aspirates from 17 of 66 patients, later diagnosed with HPV-positive oropharyngeal SCC, were HPV16 DNA-positive. HPV16 mRNA was detected in all cases with extractable RNA. All remaining FNACs, including 18 branchial cleft cysts, were HPV DNA-negative. HPV DNA status in the aspirates showed perfect concordance with corresponding biopsies. Conclusion. HPV16 DNA detection in fine-needle aspirations from neck masses is reliable and HPV16 DNA in a metastasis is a strong indicator of an HPV-positive oropharyngeal SCC.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Landin, DavidKarolinska Institutet (author)
  • Haeggblom, LinneaKarolinska Institutet (author)
  • Tertipis, NikolaosKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (author)
  • Grun, NathalieKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (author)
  • Bersani, CinziaKarolinska Institutet (author)
  • Marklund, LindaKarolinska Institutet (author)
  • Ghaderi, MehranKarolinska Institutet (author)
  • Nasman, AndersKarolinska Institutet (author)
  • Ramqvist, TorbjornKarolinska Institutet (author)
  • Nordfors, CeciliaKarolinska Institutet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (author)
  • Munck-Wikland, EvaKarolinska Institutet (author)
  • Tani, EdneiaKarolinska Institutet (author)
  • Dalianis, TinaKarolinska Institutet (author)
  • Karolinska InstitutetKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (creator_code:org_t)

Related titles

  • In:Head and Neck: Wiley39:3, s. 419-4261043-30741097-0347

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