WFRF:(Rudolf P)
Sökning: WFRF:(Rudolf P) > Meta-analysis of up...
- 27 av 162
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11770naa a2202485 4500 | |
| 001 | oai:DiVA.org:umu-156372 | |
| 003 | SwePub | |
| 008 | 190213s2020 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:d939d820-b3da-4796-94dd-d373d1756262 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1563722 URI |
| 024 | 7 | a https://doi.org/10.1038/s41380-018-0313-02 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/d939d820-b3da-4796-94dd-d373d17562622 URI |
| 040 | a (SwePub)umud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Erzurumluoglu, A. Mesutu University of Leicester4 aut |
| 245 | 1 0 | a Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci |
| 264 | c 2019-01-07 | |
| 264 | 1 | b Nature Publishing Group,c 2020 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10-8 in either analysis were taken forward for replication in up to 275,596 independent participants from UK Biobank. Lastly, a meta-analysis of the discovery and replication studies was performed. Sixteen SNVs were associated with at least one of the smoking behaviour traits (P < 5 × 10-8) in the discovery samples. Ten novel SNVs, including rs12616219 near TMEM182, were followed-up and five of them (rs462779 in REV3L, rs12780116 in CNNM2, rs1190736 in GPR101, rs11539157 in PJA1, and rs12616219 near TMEM182) replicated at a Bonferroni significance threshold (P < 4.5 × 10-3) with consistent direction of effect. A further 35 SNVs were associated with smoking behaviour traits in the discovery plus replication meta-analysis (up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2. Functional follow-up implied that decreased expression of REV3L may lower the probability of smoking initiation. The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Liu, Mengzhen4 aut |
| 700 | 1 | a Jackson, Victoria E.4 aut |
| 700 | 1 | a Barnes, Daniel R.4 aut |
| 700 | 1 | a Datta, Gargi4 aut |
| 700 | 1 | a Melbourne, Carl A.4 aut |
| 700 | 1 | a Young, Robin4 aut |
| 700 | 1 | a Batini, Chiara4 aut |
| 700 | 1 | a Surendran, Praveen4 aut |
| 700 | 1 | a Jiang, Tao4 aut |
| 700 | 1 | a Adnan, Sheikh Daud4 aut |
| 700 | 1 | a Afaq, Saima4 aut |
| 700 | 1 | a Agrawal, Arpana4 aut |
| 700 | 1 | a Altmaier, Elisabeth4 aut |
| 700 | 1 | a Antoniou, Antonis C.4 aut |
| 700 | 1 | a Asselbergs, Folkert W.4 aut |
| 700 | 1 | a Baumbach, Clemens4 aut |
| 700 | 1 | a Bierut, Laura4 aut |
| 700 | 1 | a Bertelsen, Sarah4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Bots, Michiel L4 aut |
| 700 | 1 | a Brazel, David M4 aut |
| 700 | 1 | a Chambers, John C4 aut |
| 700 | 1 | a Chang-Claude, Jenny4 aut |
| 700 | 1 | a Chen, Chu4 aut |
| 700 | 1 | a Corley, Janie4 aut |
| 700 | 1 | a Chou, Yi-Ling4 aut |
| 700 | 1 | a David, Sean P4 aut |
| 700 | 1 | a de Boer, Rudolf A4 aut |
| 700 | 1 | a de Leeuw, Christiaan A4 aut |
| 700 | 1 | a Dennis, Joe G4 aut |
| 700 | 1 | a Dominiczak, Anna F4 aut |
| 700 | 1 | a Dunning, Alison M4 aut |
| 700 | 1 | a Easton, Douglas F4 aut |
| 700 | 1 | a Eaton, Charles4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Evangelou, Evangelos4 aut |
| 700 | 1 | a Faul, Jessica D4 aut |
| 700 | 1 | a Foroud, Tatiana4 aut |
| 700 | 1 | a Goate, Alison4 aut |
| 700 | 1 | a Gong, Jian4 aut |
| 700 | 1 | a Grabe, Hans J4 aut |
| 700 | 1 | a Haessler, Jeff4 aut |
| 700 | 1 | a Haiman, Christopher4 aut |
| 700 | 1 | a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
| 700 | 1 | a Hammerschlag, Anke R4 aut |
| 700 | 1 | a Harris, Sarah E4 aut |
| 700 | 1 | a Hattersley, Andrew4 aut |
| 700 | 1 | a Heath, Andrew4 aut |
| 700 | 1 | a Hsu, Chris4 aut |
| 700 | 1 | a Iacono, William G4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Kapoor, Manav4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Kardia, Sharon L4 aut |
| 700 | 1 | a Karpe, Fredrik4 aut |
| 700 | 1 | a Kontto, Jukka4 aut |
| 700 | 1 | a Kooner, Jaspal S4 aut |
| 700 | 1 | a Kooperberg, Charles4 aut |
| 700 | 1 | a Kuulasmaa, Kari4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lai, Dongbing4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Le, Nhung4 aut |
| 700 | 1 | a Lettre, Guillaume4 aut |
| 700 | 1 | a Loukola, Anu4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Madden, Pamela A F4 aut |
| 700 | 1 | a Mangino, Massimou University of Cambridge4 aut |
| 700 | 1 | a Marioni, Riccardo E4 aut |
| 700 | 1 | a Marouli, Eirini4 aut |
| 700 | 1 | a Marten, Jonathan4 aut |
| 700 | 1 | a Martin, Nicholas G4 aut |
| 700 | 1 | a McGue, Matt4 aut |
| 700 | 1 | a Michailidou, Kyriaki4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Moayyeri, Alireza4 aut |
| 700 | 1 | a Moitry, Marie4 aut |
| 700 | 1 | a Müller-Nurasyid, Martina4 aut |
| 700 | 1 | a Naheed, Aliya4 aut |
| 700 | 1 | a Nauck, Matthias4 aut |
| 700 | 1 | a Neville, Matthew J4 aut |
| 700 | 1 | a Nielsen, Sune Fallgaard4 aut |
| 700 | 1 | a North, Kari4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Pharoah, Paul D P4 aut |
| 700 | 1 | a Pistis, Giorgio4 aut |
| 700 | 1 | a Polderman, Tinca J4 aut |
| 700 | 1 | a Posthuma, Danielle4 aut |
| 700 | 1 | a Poulter, Neil4 aut |
| 700 | 1 | a Qaiser, Beenish4 aut |
| 700 | 1 | a Rasheed, Asif4 aut |
| 700 | 1 | a Reiner, Alex4 aut |
| 700 | 1 | a Renstrom, Fridau Umeå University,Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Genetic and Molecular Epidemiology Unit, Lund University,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-frm |
| 700 | 1 | a Rice, John4 aut |
| 700 | 1 | a Rohde, Rebecca4 aut |
| 700 | 1 | a Rolandsson, Olovu Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005 |
| 700 | 1 | a Samani, Nilesh J4 aut |
| 700 | 1 | a Samuel, Maria4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Scholte, Steven H4 aut |
| 700 | 1 | a Scott, Robert A4 aut |
| 700 | 1 | a Sever, Peter4 aut |
| 700 | 1 | a Shao, Yaming4 aut |
| 700 | 1 | a Shrine, Nick4 aut |
| 700 | 1 | a Smith, Jennifer A4 aut |
| 700 | 1 | a Starr, John M4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Stram, Danielle4 aut |
| 700 | 1 | a Stringham, Heather M4 aut |
| 700 | 1 | a Tachmazidou, Ioanna4 aut |
| 700 | 1 | a Tardif, Jean-Claude4 aut |
| 700 | 1 | a Thompson, Deborah J4 aut |
| 700 | 1 | a Tindle, Hilary A4 aut |
| 700 | 1 | a Tragante, Vinicius4 aut |
| 700 | 1 | a Trompet, Stella4 aut |
| 700 | 1 | a Turcot, Valerie4 aut |
| 700 | 1 | a Tyrrell, Jessica4 aut |
| 700 | 1 | a Vaartjes, Ilonca4 aut |
| 700 | 1 | a van der Leij, Andries R4 aut |
| 700 | 1 | a van der Meer, Peter4 aut |
| 700 | 1 | a V. Varga, Tiboru Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-tv_ |
| 700 | 1 | a Verweij, Niek4 aut |
| 700 | 1 | a Völzke, Henry4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Warren, Helen R4 aut |
| 700 | 1 | a Weir, David R4 aut |
| 700 | 1 | a Weiss, Stefan4 aut |
| 700 | 1 | a Wetherill, Leah4 aut |
| 700 | 1 | a Yaghootkar, Hanieh4 aut |
| 700 | 1 | a Yavas, Ersin4 aut |
| 700 | 1 | a Jiang, Yu4 aut |
| 700 | 1 | a Chen, Fang4 aut |
| 700 | 1 | a Zhan, Xiaowei4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Zhao, Weiu Department of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA4 aut |
| 700 | 1 | a Zhao, Weiu Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA4 aut |
| 700 | 1 | a Zhou, Kaixin4 aut |
| 700 | 1 | a Amouyel, Philippe4 aut |
| 700 | 1 | a Blankenberg, Stefan4 aut |
| 700 | 1 | a Caulfield, Mark J4 aut |
| 700 | 1 | a Chowdhury, Rajiv4 aut |
| 700 | 1 | a Cucca, Francesco4 aut |
| 700 | 1 | a Deary, Ian J4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Di Angelantonio, Emanuele4 aut |
| 700 | 1 | a Ferrario, Marco4 aut |
| 700 | 1 | a Ferrières, Jean4 aut |
| 700 | 1 | a Franks, Paulu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,Harvard T.H. Chan School of Public Health4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Frayling, Tim M4 aut |
| 700 | 1 | a Frossard, Philippe4 aut |
| 700 | 1 | a Hall, Ian P4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Jansson, Jan-Håkanu Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.4 aut0 (Swepub:umu)jaja0006 |
| 700 | 1 | a Jukema, J Wouter4 aut |
| 700 | 1 | a Kee, Frank4 aut |
| 700 | 1 | a Männistö, Satu4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Munroe, Patricia B4 aut |
| 700 | 1 | a Nordestgaard, Børge Grønne4 aut |
| 700 | 1 | a Palmer, Colin N A4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Sattar, Naveed4 aut |
| 700 | 1 | a Spector, Timothy4 aut |
| 700 | 1 | a Strachan, David Peter4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Zeggini, Eleftheria4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Butterworth, Adam S4 aut |
| 700 | 1 | a Wain, Louise V4 aut |
| 700 | 1 | a Abecasis, Goncalo R4 aut |
| 700 | 1 | a Danesh, Johnu Pennsylvania State University College of Medicine4 aut |
| 700 | 1 | a Tobin, Martin D4 aut |
| 700 | 1 | a Vrieze, Scott4 aut |
| 700 | 1 | a Liu, Dajiang J4 aut |
| 700 | 1 | a Howson, Joanna M M4 aut |
| 710 | 2 | a University of Leicesterb Näringsforskning4 org |
| 710 | 2 | a Understanding Society Scientific Group |
| 773 | 0 | t Molecular Psychiatryd : Nature Publishing Groupg 25:10, s. 2392-2409q 25:10<2392-2409x 1359-4184x 1476-5578 |
| 856 | 4 | u https://doi.org/10.1038/s41380-018-0313-0y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1288340/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.nature.com/articles/s41380-018-0313-0.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41380-018-0313-0x freey FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156372 |
| 856 | 4 8 | u https://doi.org/10.1038/s41380-018-0313-0 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/d939d820-b3da-4796-94dd-d373d1756262 |
- 27 av 162
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Erzurumluoglu, A ...
- Liu, Mengzhen
- Jackson, Victori ...
- Barnes, Daniel R ...
- Datta, Gargi
- Melbourne, Carl ...
- visa fler...
- Young, Robin
- Batini, Chiara
- Surendran, Prave ...
- Jiang, Tao
- Adnan, Sheikh Da ...
- Afaq, Saima
- Agrawal, Arpana
- Altmaier, Elisab ...
- Antoniou, Antoni ...
- Asselbergs, Folk ...
- Baumbach, Clemen ...
- Bierut, Laura
- Bertelsen, Sarah
- Boehnke, Michael
- Bots, Michiel L
- Brazel, David M
- Chambers, John C
- Chang-Claude, Je ...
- Chen, Chu
- Corley, Janie
- Chou, Yi-Ling
- David, Sean P
- de Boer, Rudolf ...
- de Leeuw, Christ ...
- Dennis, Joe G
- Dominiczak, Anna ...
- Dunning, Alison ...
- Easton, Douglas ...
- Eaton, Charles
- Elliott, Paul
- Evangelou, Evang ...
- Faul, Jessica D
- Foroud, Tatiana
- Goate, Alison
- Gong, Jian
- Grabe, Hans J
- Haessler, Jeff
- Haiman, Christop ...
- Hallmans, Göran, ...
- Hammerschlag, An ...
- Harris, Sarah E
- Hattersley, Andr ...
- Heath, Andrew
- Hsu, Chris
- Iacono, William ...
- Kanoni, Stavroul ...
- Kapoor, Manav
- Kaprio, Jaakko
- Kardia, Sharon L
- Karpe, Fredrik
- Kontto, Jukka
- Kooner, Jaspal S
- Kooperberg, Char ...
- Kuulasmaa, Kari
- Laakso, Markku
- Lai, Dongbing
- Langenberg, Clau ...
- Le, Nhung
- Lettre, Guillaum ...
- Loukola, Anu
- Luan, Jian'an
- Madden, Pamela A ...
- Mangino, Massimo
- Marioni, Riccard ...
- Marouli, Eirini
- Marten, Jonathan
- Martin, Nicholas ...
- McGue, Matt
- Michailidou, Kyr ...
- Mihailov, Evelin
- Moayyeri, Alirez ...
- Moitry, Marie
- Müller-Nurasyid, ...
- Naheed, Aliya
- Nauck, Matthias
- Neville, Matthew ...
- Nielsen, Sune Fa ...
- North, Kari
- Perola, Markus
- Pharoah, Paul D ...
- Pistis, Giorgio
- Polderman, Tinca ...
- Posthuma, Daniel ...
- Poulter, Neil
- Qaiser, Beenish
- Rasheed, Asif
- Reiner, Alex
- Renstrom, Frida
- Rice, John
- Rohde, Rebecca
- Rolandsson, Olov
- Samani, Nilesh J
- Samuel, Maria
- Schlessinger, Da ...
- Scholte, Steven ...
- Scott, Robert A
- Sever, Peter
- Shao, Yaming
- Shrine, Nick
- Smith, Jennifer ...
- Starr, John M
- Stirrups, Kathle ...
- Stram, Danielle
- Stringham, Heath ...
- Tachmazidou, Ioa ...
- Tardif, Jean-Cla ...
- Thompson, Debora ...
- Tindle, Hilary A
- Tragante, Vinici ...
- Trompet, Stella
- Turcot, Valerie
- Tyrrell, Jessica
- Vaartjes, Ilonca
- van der Leij, An ...
- van der Meer, Pe ...
- V. Varga, Tibor
- Verweij, Niek
- Völzke, Henry
- Wareham, Nichola ...
- Warren, Helen R
- Weir, David R
- Weiss, Stefan
- Wetherill, Leah
- Yaghootkar, Hani ...
- Yavas, Ersin
- Jiang, Yu
- Chen, Fang
- Zhan, Xiaowei
- Zhang, Weihua
- Zhao, Wei
- Zhou, Kaixin
- Amouyel, Philipp ...
- Blankenberg, Ste ...
- Caulfield, Mark ...
- Chowdhury, Rajiv
- Cucca, Francesco
- Deary, Ian J
- Deloukas, Panos
- Di Angelantonio, ...
- Ferrario, Marco
- Ferrières, Jean
- Franks, Paul
- Frayling, Tim M
- Frossard, Philip ...
- Hall, Ian P
- Hayward, Carolin ...
- Jansson, Jan-Håk ...
- Jukema, J Wouter
- Kee, Frank
- Männistö, Satu
- Metspalu, Andres
- Munroe, Patricia ...
- Nordestgaard, Bø ...
- Palmer, Colin N ...
- Salomaa, Veikko
- Sattar, Naveed
- Spector, Timothy
- Strachan, David ...
- van der Harst, P ...
- Zeggini, Elefthe ...
- Saleheen, Danish
- Butterworth, Ada ...
- Wain, Louise V
- Abecasis, Goncal ...
- Danesh, John
- Tobin, Martin D
- Vrieze, Scott
- Liu, Dajiang J
- Howson, Joanna M ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Medicinsk geneti ...
- Artiklar i publikationen
- Molecular Psychi ...
- Av lärosätet
- Umeå universitet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
