Identification of functional elements and regulatory circuits by Drosophila modENCODE.

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MARC

Fältnamn	Indikatorer	Metadata
000		05808naa a2201405 4500
001		oai:DiVA.org:umu-46221
003		SwePub
008		110829s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-462212 URI
024	7	a https://doi.org/10.1126/science.11983742 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Roy, Sushmita4 aut
245	1 0	a Identification of functional elements and regulatory circuits by Drosophila modENCODE.
264	1	b American Association for the Advancement of Science (AAAS),c 2010
338		a print2 rdacarrier
520		a To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation.
700	1	a Ernst, Jason4 aut
700	1	a Kharchenko, Peter V4 aut
700	1	a Kheradpour, Pouya4 aut
700	1	a Negre, Nicolas4 aut
700	1	a Eaton, Matthew L4 aut
700	1	a Landolin, Jane M4 aut
700	1	a Bristow, Christopher A4 aut
700	1	a Ma, Lijia4 aut
700	1	a Lin, Michael F4 aut
700	1	a Washietl, Stefan4 aut
700	1	a Arshinoff, Bradley I4 aut
700	1	a Ay, Ferhat4 aut
700	1	a Meyer, Patrick E4 aut
700	1	a Robine, Nicolas4 aut
700	1	a Washington, Nicole L4 aut
700	1	a Di Stefano, Luisa4 aut
700	1	a Berezikov, Eugene4 aut
700	1	a Brown, Christopher D4 aut
700	1	a Candeias, Rogerio4 aut
700	1	a Carlson, Joseph W4 aut
700	1	a Carr, Adrian4 aut
700	1	a Jungreis, Irwin4 aut
700	1	a Marbach, Daniel4 aut
700	1	a Sealfon, Rachel4 aut
700	1	a Tolstorukov, Michael Y4 aut
700	1	a Will, Sebastian4 aut
700	1	a Alekseyenko, Artyom A4 aut
700	1	a Artieri, Carlo4 aut
700	1	a Booth, Benjamin W4 aut
700	1	a Brooks, Angela N4 aut
700	1	a Dai, Qi4 aut
700	1	a Davis, Carrie A4 aut
700	1	a Duff, Michael O4 aut
700	1	a Feng, Xin4 aut
700	1	a Gorchakov, Andrey A4 aut
700	1	a Gu, Tingting4 aut
700	1	a Henikoff, Jorja G4 aut
700	1	a Kapranov, Philipp4 aut
700	1	a Li, Renhua4 aut
700	1	a MacAlpine, Heather K4 aut
700	1	a Malone, John4 aut
700	1	a Minoda, Aki4 aut
700	1	a Nordman, Jared4 aut
700	1	a Okamura, Katsutomo4 aut
700	1	a Perry, Marc4 aut
700	1	a Powell, Sara K4 aut
700	1	a Riddle, Nicole C4 aut
700	1	a Sakai, Akiko4 aut
700	1	a Samsonova, Anastasia4 aut
700	1	a Sandler, Jeremy E4 aut
700	1	a Schwartz, Yuri Bu Rutgers University, New Jersey, USA4 aut0 (Swepub:umu)yusc0002
700	1	a Sher, Noa4 aut
700	1	a Spokony, Rebecca4 aut
700	1	a Sturgill, David4 aut
700	1	a van Baren, Marijke4 aut
700	1	a Wan, Kenneth H4 aut
700	1	a Yang, Li4 aut
700	1	a Yu, Charles4 aut
700	1	a Feingold, Elise4 aut
700	1	a Good, Peter4 aut
700	1	a Guyer, Mark4 aut
700	1	a Lowdon, Rebecca4 aut
700	1	a Ahmad, Kami4 aut
700	1	a Andrews, Justen4 aut
700	1	a Berger, Bonnie4 aut
700	1	a Brenner, Steven E4 aut
700	1	a Brent, Michael R4 aut
700	1	a Cherbas, Lucy4 aut
700	1	a Elgin, Sarah C R4 aut
700	1	a Gingeras, Thomas R4 aut
700	1	a Grossman, Robert4 aut
700	1	a Hoskins, Roger A4 aut
700	1	a Kaufman, Thomas C4 aut
700	1	a Kent, William4 aut
700	1	a Kuroda, Mitzi I4 aut
700	1	a Orr-Weaver, Terry4 aut
700	1	a Perrimon, Norbert4 aut
700	1	a Pirrotta, Vincenzo4 aut
700	1	a Posakony, James W4 aut
700	1	a Ren, Bing4 aut
700	1	a Russell, Steven4 aut
700	1	a Cherbas, Peter4 aut
700	1	a Graveley, Brenton R4 aut
700	1	a Lewis, Suzanna4 aut
700	1	a Micklem, Gos4 aut
700	1	a Oliver, Brian4 aut
700	1	a Park, Peter J4 aut
700	1	a Celniker, Susan E4 aut
700	1	a Henikoff, Steven4 aut
700	1	a Karpen, Gary H4 aut
700	1	a Lai, Eric C4 aut
700	1	a MacAlpine, David M4 aut
700	1	a Stein, Lincoln D4 aut
700	1	a White, Kevin P4 aut
700	1	a Kellis, Manolis4 aut
710	2	a Rutgers University, New Jersey, USA4 org
773	0	t Science (New York, N.Y.)d : American Association for the Advancement of Science (AAAS)g 330:6012, s. 1787-1797q 330:6012<1787-1797x 1095-9203x 0036-8075
856	4	u https://dspace.mit.edu/bitstream/1721.1/79870/2/Berger_Identification%20of%20functional.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46221
856	4 8	u https://doi.org/10.1126/science.1198374

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By the author/editor: Roy, Sushmita; Ernst, Jason; Kharchenko, Pete ...; Kheradpour, Pouy ...; Negre, Nicolas; Eaton, Matthew L; show more...; Landolin, Jane M; Bristow, Christo ...; Ma, Lijia; Lin, Michael F; Washietl, Stefan; Arshinoff, Bradl ...; Ay, Ferhat; Meyer, Patrick E; Robine, Nicolas; Washington, Nico ...; Di Stefano, Luis ...; Berezikov, Eugen ...; Brown, Christoph ...; Candeias, Rogeri ...; Carlson, Joseph ...; Carr, Adrian; Jungreis, Irwin; Marbach, Daniel; Sealfon, Rachel; Tolstorukov, Mic ...; Will, Sebastian; Alekseyenko, Art ...; Artieri, Carlo; Booth, Benjamin ...; Brooks, Angela N; Dai, Qi; Davis, Carrie A; Duff, Michael O; Feng, Xin; Gorchakov, Andre ...; Gu, Tingting; Henikoff, Jorja ...; Kapranov, Philip ...; Li, Renhua; MacAlpine, Heath ...; Malone, John; Minoda, Aki; Nordman, Jared; Okamura, Katsuto ...; Perry, Marc; Powell, Sara K; Riddle, Nicole C; Sakai, Akiko; Samsonova, Anast ...; Sandler, Jeremy ...; Schwartz, Yuri B; Sher, Noa; Spokony, Rebecca; Sturgill, David; van Baren, Marij ...; Wan, Kenneth H; Yang, Li; Yu, Charles; Feingold, Elise; Good, Peter; Guyer, Mark; Lowdon, Rebecca; Ahmad, Kami; Andrews, Justen; Berger, Bonnie; Brenner, Steven ...; Brent, Michael R; Cherbas, Lucy; Elgin, Sarah C R; Gingeras, Thomas ...; Grossman, Robert; Hoskins, Roger A; Kaufman, Thomas ...; Kent, William; Kuroda, Mitzi I; Orr-Weaver, Terr ...; Perrimon, Norber ...; Pirrotta, Vincen ...; Posakony, James ...; Ren, Bing; Russell, Steven; Cherbas, Peter; Graveley, Brento ...; Lewis, Suzanna; Micklem, Gos; Oliver, Brian; Park, Peter J; Celniker, Susan ...; Henikoff, Steven; Karpen, Gary H; Lai, Eric C; MacAlpine, David ...; Stein, Lincoln D; White, Kevin P; Kellis, Manolis; show less...

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